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Bicalutamide
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Bicalutamide

Bicalutamide is an oral medication that is used for treating cancer of the prostate. It belongs to a class of drugs called anti-androgens which includes flutamide (Eulexin) and nilutamide (Nilandron). Androgens (an example of which is testosterone) are hormones that are produced and released by the adrenal glands. They are responsible for supporting (stimulating) tissues that primarily are thought of as male, for example, the male prostate gland. Male traits that also are influenced by androgens include facial and body hair, and small breasts. Anti-androgens prevent the action of androgens by blocking the receptors for androgens on the cells of tissues, for example, the cells of the prostate gland. In addition to normal prostate cells, androgens also have been shown to stimulate the growth of cancer cells within the prostate. Bicalutamide is thought to prevent the growth of prostate cancer by blocking the effects of androgens on the cancer cells. Bicalutamide was approved by the FDA in 1995.

Other names for this medication:
Bicalutamide, Casodex, Bicalox, Bicalutamida, Bicusan, Bidrostat, Caluran, Calutide, Calutol, Capro, Cosudex, Imda, Lutamidal, Probic, Zolacos,

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Rantec, Cobese, Zolway, Dolotram, Klindan, Rozavel, Jufurix, Ovel, Stafcure, Vetrimoxin, Nefazan, Dolonex, Sizodon, Elkostop, Abacavir, Sumitrex, Velamox, Aceon, Ketipinor, Kenazole, Allerstat, Selgin, Pacerone, Dols, Amovet, Diulo, Klomen, Exipan,

Bicalutamide comes as a tablet to take by mouth. It is usually taken with or without food once a day, either in the morning or evening. Take bicalutamide at around the same time every day. You should begin taking bicalutamide on the same day you begin injecting the luteinizing hormone-releasing hormone. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take bicalutamide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Bicalutamide along with the luteinizing hormone-releasing hormone may help stop the growth and spread of cancer cells but does not cure prostate cancer. Continue to take both bicalutamide and the luteinizing hormone-releasing hormone even if you feel better. Do not stop taking these medications without talking to your doctor.

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Of all the variables, provocation was the strongest elicitor of aggression. We compared the results obtained in 1999 for all patients who visited the emergency room for chest pain and the patients who were hospitalized.

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Functional studies have shown many of these conserved sites to be transcriptional regulatory elements that sometimes reside inside unrelated neighboring genes. Adenoviral GDNF gene transfer prevents motoneuron loss in the nucleus ambiguus. Culturally-adapted and audio-technology assisted HIV/AIDS awareness and education program in rural Nigeria: a cohort study. Observed differences in retardation between healthy eyes and eyes with experimental glaucoma suggest that scanning laser polarimetry may be useful for detecting and monitoring RNFL loss in experimental primate glaucoma.

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Between March and June 2006, a pilot study was conducted to determine the feasibility of the safe port plug technique using the Bioabsorbable Hernia Plug to prevent incisional hernia in trocar sites. But what he wrote on his official blog on the HHS Web site caused a flurry of news coverage and renewed interest from Congress. Currently, however, there exist no generally agreed upon guidelines based on which tests and testing algorithms should be used to confirm and locate or exclude a suspected pheochromocytoma.

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The decrease of PGP9.5 and TRPV1 immunoreactive nerve fibres in responders to resiniferatoxin (to levels in control tissues) suggests that the increased numbers of nerve fibres in patients with NDO are mainly of sensory origin and express TRPV1. The results of the isolated posterior cruciate ligament injury group were better than the combined ligamentous injury group. The authors report the experience of the Italian Cooperative Study AIEOP-CNR RMS-79 concerning 16 children affected by localized paratesticular rhabdomyosarcoma (15 stage I, 1 stage II). This method is tested on polyhydroxy molecules at MP2 and B3LYP levels of theory.

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To discuss the correlation of ultrasonographic grading of varicocele (VC) with the changes of seminal parameters after varicocelectomy. Here we show that a recombination-promoting complex (RPC) containing Swi2 and Swi5 proteins exhibits cell type-specific localization pattern at the silent mating-type region and this differential localization modulates donor preference during mating-type switching. Moreover, peroxisome proliferator activated receptor-gamma coactivator-1 (PGC-1alpha) and PGC-1-related estrogen receptor coactivator (PERC) robustly increase the transcriptional function of ERalpha in the presence of the ERRE. At 13 Michigan EDs, interviews were conducted with parents of children aged 6 months to 18 years who were triaged by ED personnel as lowest acuity.

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Combination therapy of thymalfasin (thymosin-alpha 1) and peginterferon alfa-2a in patients with chronic hepatitis C virus infection who are non-responders to standard treatment. WMS-R verbal memory and learning parameters did not significantly correlate with D2/D3 receptor binding potential (BP(ND)) in the studied cortical regions. The rationale behind preventive vaccination is that patients with minimal tumor burden still have a fully competent immune system capable of developing robust antitumor responses.

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For example, tumor necrosis factor not only induces proapoptotic signals via the caspase cascade but also activates intracellular survival pathways, namely the nuclear factor (NF)-kappaB pathway. Taken together, these results indicated that HCMV increasingly regulates the subcellular distribution and abundance of essential RNA-processing factors, thereby altering their ability to affect the processing of viral pre-mRNAs. It has been shown that this treatment is effective in patients with haemophilia and an inhibiting antibody against a coagulation factor. Our results show that UN modifies osteoblast cell metabolism by increasing ROS generation and reducing APh activity, suggesting that ROS may play a more complex role in cell physiology than simply causing oxidative damage.

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As a result of competition between the ultrafast processes, for TiO2 singlet, whereas for SnO2 triplet electron injection is dominant. During a period of 2 y, 15 patients with fatty livers diagnosed as having nonalcoholic steatohepatitis underwent hepatobiliary scintigraphy using the radiopharmaceutical agent (99m)Tc-labeled mebrofenin. A descriptive analysis was provided with adjustments, means, proportions, ratios, percentages of increase or reduction, and mobile means. Assessment of bone turnover in term and preterm newborns at birth: measurement of urinary collagen crosslink excretion.

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Recombinant human thyroid peroxidase expressed in insect cells is soluble at high concentrations and forms diffracting crystals. Critical issues for the application of drug carrier systems will be discussed, focusing on biopharmaceutical and pathophysiological parameters such as routes of application, improvement of body distribution and targeting intracellularly persisting pathogens. P-glycoprotein (Pgp) is an efflux pump that protects vital organs like the brain from toxic substances, but which is also associated with therapy resistance.

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There were 65 ureteroscopies performed, of them 59 cases for the reason of ureterolithiasis. Significant genotypic differences were obtained in canopy-air temperature difference (Tc-Ta), r(c) and 1 / r(c) during the 2-week period preceding full heading for two years, and 1 / r(c) was highly correlated with crop growth rate (CGR), which was closely related to the final yield. What do we know about the mechanism of action of disease-modifying treatments in MS? Validation of a six-task simulation model in minimally invasive surgery.

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The experience of phantom limb pain in patients with combat-related traumatic amputations. Neutral and acid glycoconjugates were detected mainly in the cytoplasm of the surface cells of the columnar stratified epithelial lining. Expression of alpha(2)A and alpha(2)C, but not alpha(2)B, was confirmed in the myocyte population by indirect immunofluorescence microscopy with subtype-specific antibodies and by Western blot. A rationale for utilizing an integrated approach, the challenges inherent to developing such an approach, and suggestions for working toward integrated approaches aimed at preventing the broad spectrum of weight-related disorders are discussed.

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HPV infection of normal oral epithelial cells for immortalization (approximately premalignant cells) coupled with transformation with carcinogens (malignant cells) has established an experimental model for progression. This differential expression of galectin-3 between histological types of lung carcinoma suggests that galectin-3 may have an important influence on tumour cell adhesion, apoptosis and the response of tumours to chemotherapy.

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To investigate the nature of molecular lesions causing this disease, mutations in the cathepsin K gene from eight families were determined, identifying seven novel mutations (K52X, G79E, Q190X, Y212C, A277E, A277V, and R312G). In a group of 13 patients operated consecutively using this technique, there was no significant increase in the diameters of the neo-aortic root after a mean 16-month follow-up.

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Antiretroviral therapy with combination zidovudine and interferon alfa, which induces a high rate of complete remission and lengthens survival, should be the first treatment option in acute adult T-cell leukaemia. Blind and bilateral conjunctival biopsy, due to its ease, safety and specificity, could be the first biopsy inpatients with clinical or chest X-ray abnormalities suggesting sarcoidosis. Change in Modic type 1 and 2 signals after posterolateral fusion surgery. Results indicate a pronounced elevation effect (0.2 per thousand and 1 to 2 per thousand per 100 m for delta(18)O and delta(2)H, respectively) as well as influence of seawater mixing for a few coastal locations. This can provide continuous 3D feedback to assist in guiding an interventional procedure.

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The Orthopedic Department at the University of Heidelberg, Germany. In the case reported, the demise of one twin was diagnosed by ultrasonography in an asymptomatic 21-year-old para 1-0-2-1 African American at the gestational age of 25 weeks. This has given rise to considerable concern over the safety of aging shift workers because of the increasing age of the work force and increases in retirement age. We describe our experience in 21 consecutive adult lung transplantations using nonheparinized category III NHB donors and standard flush preservation. Furthermore, alpha3-KO mice did not differ in seizure susceptibility in a model of temporal lobe epilepsy.

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The ratio of rates of 24-hydroxylation of 1 alpha-hydroxyvitamin D(3) (1 alpha OHD(3)), 1 alpha OHD(2), and vitamin D(2) by CYP3A4 was 3.6/2.8/1.0. Damage of white matter in the parietal lobe results in anomic alexia of kana. MVP can occur in the context of genetic syndromes, including Marfan syndrome (MFS), an autosomal-dominant connective tissue disorder caused by mutations in fibrillin-1.

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Syrian golden hamsters were implanted with fixed or moveable stimulating electrodes aimed at the superior colliculus (SC). Infections associated with dental procedures in total hip arthroplasty. In reply: auger electron angular distributions from surfaces: forward focusing or silhouettes?

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Data for patients who had peripheral NSCLC with well-defined borders on CT and SUV(max) of greater than 2.5 were reviewed. The protein kinase Fused (Fu) is an integral member of the Hedgehog (Hh) signaling pathway. Improved efficiency of a Salmonella-based vaccine against human papillomavirus type 16 virus-like particles achieved by using a codon-optimized version of L1.

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Interferon-inhibited human osteosarcoma xenografts induce host bone in nude mice. Blood samples were taken at baseline and every 4 weeks during the whole treatment and 24 weeks of follow-up period. We estimated the incidence and natural course of nocturia in an unselected Finnish male population. However, carpal tunnel syndrome may also be caused by space-occupying lesions within the carpal canal that compress the median nerve.

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A good software package should be easy to use, able to provide readable documentation, flexible enough to accommodate change, and have a proven record of success. These peaks can arise only in the case of the designated SDS protons and maltodextrin protons being less than 0.5 nm apart for a substantial period of time. Human duct cell-released IL-8 and VEGF may help revascularization of currently used human islet cell grafts.

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The goal of obtaining protein structures on a genomic scale has motivated the development of high-throughput technologies for macromolecular structure determination, which have begun to produce structures at a greater rate than previously possible. In the untreated HF model rats, gene expression of MMP-2 and MMP-9 and tissue gelatinase activity were elevated at 23 weeks without LV dilatation. However, the steroid(s) responsible for hypertension in MR(L810) carriers (men and nonpregnant women) has not yet been identified. In the postoperative period rhinorrhea and meningitis, which lasted for two days, developed in one patient with fracture of frontal sinus anterior-posterior walls and hypoestesia developed in the frontal skin area in one patient with fracture of frontal sinus anterior wall.

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Patients with oral maxillofacial cancer usually have protein-energy malnutrition. Gazing anew: the shift from a clinical gaze to an ethnographic lens. We found that transfer of newts, Cynops pyrrhogaster, to low temperature (8 and 12 degrees C) caused cell death of spermatogonia just before meiosis and elevation of prolactin concentration in the newt plasma. The patient was resuscitated and recovered without significant systemic injury.

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