FREE
SHIPPING!

on all orders above $300.00

FREE Pills!

VIAGRA PILLS

for free with every order

OUR DRUG PRICES are

70%

Less than in your
local pharmacy

Search by letter:

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Enter coupon: (if you have one)

Amantan (Amantadine)
+ BONUS
 
Amantadine

Amantan for weight gain associated with olanzapine treatment. Re-emergence of Amantan-resistant variants among highly pathogenic avian influenza H5N1 viruses in Egypt. The effect of Amantan, acting as an antiglutamatergic agent, also opens new insights into the pathogenesis of PG.

Other names for this medication:
Amantadine, Symmetrel, Aman, Amantadina, Amantan, Amixx, Antadine, Lysovir, Mantadan, Mantadix, Protexin, Symadine, Tregor, Viregyt, Virosol,

Similar Products:
Taromentin, Hepcinat, Purbac, Valsacor, Medacin, Angilock, Sarvas, Bicalox, Omnix, Tavaloxx, Sofab, Diltiazem, Dicorate, Teranex, Amlovas, Trazodone, Puribel, Spasuret, Digoxin, Duinum, Flucon, Atova, Clamovid, Dobupal, Marivarin, Amitriptilina, Sylatron, Sofovir, Calutol, Flutan, Lozol, Lorez, Rheugesic, Tamiram, Atoris, Silenor, Lafigin, Proclorperazina, Danlox, Clamentin,

Amantan comes as a capsule, extended-release capsule (Gocovri), tablet, and liquid to take by mouth. The capsules, tablets, and liquid medications are usually taken once or twice a day. The extended-release capsules are taken once a day at bedtime. Take Amantan at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Amantan exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the extended-release capsules whole; do not split, chew, or crush them. If you have difficulty swallowing, you may open the extended-release capsule and sprinkle the entire contents on a teaspoonful of soft food, like applesauce. Eat the mixture right away and swallow without chewing.

If you are taking Amantan for Parkinson's disease, your doctor may start you on a low dose of Amantan and gradually increase your dose.

Do not stop taking Amantan without talking to your doctor. If you suddenly stop taking Amantan, you may experience fever, confusion, changes in mental state, or severe muscle stiffness. Your doctor will probably decrease your dose gradually.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

amantan multiple sclerosis symptoms

In the early stages of chronic non-infectious illnesses of great epidemiological significance reversible regulation disturbances, non-adaptive behavioral factors (such as smoking, alcohol abuse, etc.) are the most important risk factors, which are closely connected with emotional disturbances, anxiety, depressive symptomatology, hopelessness and learned pathological reactions. The structure- and mechanism-based computational strategies and design approaches may be used to design high-activity and/or thermostable mutants of many other proteins that have clear therapeutic potentials and to design completely new therapeutic enzymes.

amantan multiple sclerosis symptoms

Starting from a single cell at conception, sequences replicate and may drift apart. Glasgow Anxiety Scale for people with an Intellectual Disability (GAS-ID): development and psychometric properties of a new measure for use with people with mild intellectual disability.

amantan multiple sclerosis symptoms

Moreover, the current results of examinations evaluating the influence of pregnancy and delivery on the risk of relapse and deterioration of disability in the immediate and remote postpartum period and the importance of diet and rehabilitation are presented. The missing part belongs to one of the four repeated sequence family of FLO1.

amantan multiple sclerosis symptoms

Prenatal sonography and magnetic resonance imaging did not allow establishing the origin of the suprarenal mass. Five years later, the 590 patients still alive were offered eye examinations and asked to fill out the questionnaire. FISH probes were successfully obtained from DNA libraries that were amplified from microdissected sex chromosomes.

amantan multiple sclerosis symptoms

Automated tuberculosis case reporting resulted in time savings but not improved accuracy. Genetic ablation of M3 muscarinic receptors attenuates murine colon epithelial cell proliferation and neoplasia. An assay for determination of rat adrenal catechol-O-methyltransferase activity: comparison of spontaneously hypertensive rats and Wistar-Kyoto rats. In the cyanobacterium Synechococcus elongatus, the essential clock protein KaiC is proposed to form this type of transcriptional negative feedback. Furthermore, CDCA4 depletion resulted in accelerated cell proliferation, perhaps due to the disruption of CDCA4 nuclear function as a transcription suppressor.

amantan multiple sclerosis symptoms

DNA ladder pattern was the most clear in the arthropyosis group, moderately clear in the dislocation group (especially in a case of 20 years-old shoulder dislocation), less clear in the osteoarthritis group, the least clear in the meniscus injury group, and was not seen in the control group. To assess the impact of a focused academic support program on American Board of Surgery In-Training Examination (ABSITE) scores and Qualifying Examination (QE) outcomes. Immersion coating of pellet cores consisting of chitosan and calcium intended for colon drug delivery.

amantan multiple sclerosis symptoms

A 35-year-old man presented with pain in the upper abdomen of two-month duration associated with significant weight loss. Butanol-induced inhibition of K-EDTA-ATPase of myosin subfragment 1 proceeded by biphasic kinetics, consisting of rapid and slow inactivations.

amantan multiple sclerosis symptoms

The atracurium infusion was used for 71 days, the longest time ever recorded, at a mean rate of 1.3 mg/kg/hour at the end of infusion. Strain differences in the responsiveness between Sprague-Dawley and Fischer rats to nephropathy induced by FYX-051, a xanthine oxidoreductase inhibitor.

amantan multiple sclerosis symptoms

In addition, in experimental autoimmune encephalomyelitis (EAE), an animal model of MS, the blockade of ACE suppresses the disease itself. Future research is warranted to further examine the effect of medical and psychiatric comorbidity on SP course. The neurological deficits examinations were performed at 2, 24, 48 h after reperfusion. However, information on potential functional adverse effects after intersphincteric resection should be provided to patients preoperatively.

amantan multiple sclerosis symptoms

Screening for hypoglycemia at the bedside in the neonatal intensive care unit (NICU) with the Abbott PCx glucose meter. N-Succinyl-alanyl-methionyl-S-benzylcysteine p-nitroanilide has been found to be a very sensitive chromogenic substrate for the assay of cysteine proteinase papain, ficin and bromelain.

amantan multiple sclerosis symptoms

Asking, witnessing, interpreting, knowing: conducting qualitative research in community psychology. Therefore, we tested whether overexpression of Sox2 enhances pluripotency and facilitates differentiation of cMABs in cardiovascular lineages. Polynucleotide phosphorylase-based photometric assay for inorganic phosphate. ANK repeats are conserved domains of 33 amino acids involved in specific recognition of protein partners. Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics.

amantadine dosage forms of adderall

  • amantadine for dogs reviews
  • amantadine hcl dosage creatine
  • livedo reticularis caused by amantadine hcl
  • amantadine dosage forms of adderall
  • amantadine hcl solubility table
  • amantadine therapeutic effect of heparin
  • amantadine hcl 100 mg
  • amantadine mechanism of action animation background
  • amantadine uses parkinson's disease images
  • amantadine prices for 100 mgs
  • amantadine hydrochloride syrup usp
  • meythaler amantadine medication
  • mechanism of action of amantadine hcl tablets
  • amantadine hydrochloride nursing implications
  • amantadine package insert pdf in word
  • amantadine for ms fatigue reviews on garcinia
  • amantadine action in parkinson's disease
  • amantadine reviews parkinsons
  • amantadine 100 mg cost
  • amantadine 100 mg capsule picture
  • amantadine brand name in pakistan best
  • amantadine influenza mechanism of action
  • pms-amantadine side effects
  • amantadine hydrochloride usp monograph definition
  • difference between amantadine and memantine hcl
  • amantadine dosage form
  • mechanism of action of amantadine hcl
  • therapeutic effects of amantadine
  • amantadine dose for children
  • amantadine hydrochloride nursing implications for albuterol
  • amantadine drug study scribd downloader
  • side effects of amantadine hcl caps
  • amantadine side effects multiple sclerosis
  • amantadine withdrawal side effects
  • pms amantadine hcl
  • amantadine influenza treatment cdc
  • amantadine hydrochloride usp monograph polyethylene
  • amantadine side effects hallucinations from alcohol
  • amantadine rimantadine zanamivir and oseltamivir dosage
  • drug classification of amantadine
  • amantadine for ms fatigue reviews of risen
  • amantadine drug group topics
  • amantadine for dogs side effects
  • can amantadine capsules be opened gospel
  • mechanism of action of amantadine and rimantadine mechanism
  • amantadine hydrochloride side effects
  • amantadine mechanism of action parkinson's dementia
  • amantadine hcl 100mg side effects
  • amantadine hydrochloride drug interactions
  • amantadine drug category chart
  • amantadine manufacturers
  • amantadine sulphate side effects
  • amantadine hydrochloride oral solution usp
  • amantadine hydrochloride sigma
  • amantadine package insert pdf in powerpoint
  • amantadine drug category of marijuana
  • amantadine medication cream
  • amantadine hydrochloride nursing implications for drugs
  • amantadine concussion headache symptoms
  • amantadine parkinson's tremor medication
  • amantadine dosage for parkinson's
  • amantadine for ms dosage forms
  • amantan multiple sclerosis symptoms
  • amantadine stada 100 mg bijsluiter
  • amantadine 100 mg concussion showtimes
  • amantadine hydrochloride nursing implications for aspirin
  • can amantadine capsules be opened ephatha
  • amantadine mechanism of action influenza proton m2
  • amantadine hcl cap 100mg
  • amantadine mechanism action influenza 2016
  • amantadine for ms-related fatigue and pregnancy
  • amantadine uses in ms
  • amantadine dose parkinson's disease early symptoms
  • amantadine brain injury dosage calculations
  • m2 amantadine uses
  • amantadine drug group home
  • amantadine drug action of gabapentin

amantan multiple sclerosis symptoms

Sedation, analgesia, and neuromuscular blockade in sepsis: an evidence-based review. Clinical remission was always associated with normal gut histology, whereas active locomotor inflammation was usually associated with the presence of gut inflammation.

amantan multiple sclerosis symptoms

Various cephalometric dimensions reflecting facial vertical height and sagittal nasopharyngeal length were measured and compared to speech data. To research these uncultured bacteria, Directly extract crude DNA from farm soil, separate 16S rDNA mixture amplified by PCR from the crude DNA, sequence it and compare the sequences with the records of NCBI to classify the germs. Early switch from iv to oral therapy allows simpler antibiotic regimens and facilitates early discharge from hospital. Optimization of alpha-amylase production for the green synthesis of gold nanoparticles.

amantan multiple sclerosis symptoms

Imaging of ultra-weak bio-chemiluminescence and singlet oxygen generation in germinating soybean in response to wounding. Persons reporting pain are also not distinguishable from normal control subjects on a variety of self-report measures. Verapamil reduces dipyridamole-induced myocardial ischemia in patients with coronary artery disease. Solid nanotubes comprising alpha-Fe2O3 nanoparticles prepared from ferritin protein. Single-crystalline BaWO(4) and BaCrO(4) nanorods of reproducible shape and of varying sizes have been controllably prepared using a simple, room-temperature approach, based on the use of porous alumina template membranes.

amantadine hcl 100 mg

Galapagos Flora: Fernandina (Narborough) Caldera before Recent Volcanic Event. Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin. The hygiene hypothesis contends that fewer opportunities for infection have led to increases in the prevalences of asthma and other allergic diseases. Before skeletal maturity, a LLD between 2 and 5 cm can be corrected by epiphyseodesis (open or closed) or stapling. The patient developed severe postdural puncture headache (PDPH) and three episodes of pronounced vestibulocochlear disturbances within five weeks after only one dural puncture.

amantadine brain injury dosage calculations

Furthermore, leukotrienes induce endothelium-dependent and independent vascular responses. Stabilization of available arsenic in highly contaminated mine tailings using iron. This is the first report on the cleavage of HA(0) into HA(1) and HA(2) in the methylotrophic yeast P. These clinicians work in concert with critical care specialists in choosing optimal empirical regimens and in streamlining therapy once culture results are available. Change in Ucp1 mRNA expression following long-term cold exposure under normal or high-fat diet regimes in the cold-intolerant mammal, Suncus murinus.

amantadine for ms-related fatigue and pregnancy

Investigation into the effect of Fenoterol on mucociliary clearance in patients with chronic bronchitis. However, an additive effect was achieved adding the terminal halves together in the reaction, suggesting that both might play critical roles in achieving full stimulatory activity of the full-length La protein. Detection of functional homologs of the TCP island genes in environmental strains may have implications for understanding the origin and evolution of virulence genes of V. The patients were categorized into lobectomy (or pneumonectomy) combined with mediastinal LND or lymph node sampling (LNS) according to the record of their operative procedures. Moreover, combined AFB1 and OTA induced all the toxicities observed with the mycotoxins separately.

amantadine for dogs reviews

Absence of UCP3 in brown adipose tissue does not impair nonshivering thermogenesis. The microarray analysis also identified 10 transcripts with early expression kinetics, 32 transcripts with early-late expression kinetics and 29 transcripts with late expression kinetics.

amantadine 100 mg concussion showtimes

Ornithine decarboxylase in organs of rat following chronic gamma-irradiation at low dose-rates. Moreover, a significant proportion of moderate traumatic brain injury patients (managed without invasive ICP) will develop raised ICP. Some variability in binding affinity was seen in different sites, and labelling was more often on the periphery than the center of the PSX fibers. Current practice for the laparoscopic diagnosis and treatment of endometriosis and willingness to participate in a randomised trial.

amantadine withdrawal side effects

Restricted communication within the family was observed frequently. The aetiology of osteoporosis is not fully understood but it was suggested that the genetic factors could play an important role.

therapeutic effects of amantadine

We studied 95 unrelated white European patients with SLE, as defined by the American College of Rheumatology criteria, 50 of whom had a history of lupus nephritis, and 69 healthy white European control subjects. Twenty-four hours later (day 1), oral administration of semotiadil (10, 30, or 100 mg/kg per day) or diltiazem (100 or 300 mg/kg per day) was initiated. In the present study, we investigated whether the direct delivery of platelet-derived growth factor cDNA into skin results in improvement in tissue repair. Cytogenetic and molecular analyses revealed a nonsense mutation in exon 6 of the p53 gene.

amantadine parkinson's tremor medication

Assessing the qualitative and quantitative nature of lymphocyte function following immunotherapy provides valuable information about the immune responses mediated by a therapeutic agent. Our goal was to investigate the toxicity and therapeutic effect of a new therapeutic agent, Staphylococcus aureus superantigen (SSAg), a powerful T-cell stimulant administered intrapleurally to unselected, consecutive patients with MPE from NSCLC (stage IIIb with pleural effusion) and a poor performance status. Our aim is to discuss the advances on the escape mechanisms used by H. Activation of NF-kappaB is necessary for the restoration of the barrier function of an epithelium undergoing TNF-alpha-induced apoptosis.

amantadine hcl dosage creatine

They develop in neonates and are associated with feeding difficulty, airway obstruction, and difficulty in swallowing (which may cause polyhydramnios). The enantiomeric separations of 8 N-FMOC amino acids were accomplished, among which 5 N-FMOC amino acids could be on baseline separated. The results of open reduction and internal fixation of radial head fractures Data were collected from May 1, 1996, to April 30, 1999, in the North East Melbourne Stroke Incidence Study. Self-esteem and social well-being of children with cochlear implant compared to normal-hearing children.

pms amantadine hcl

Participants in a cross-sectional health screening study were examined. The extreme variability in clinical phenotype, even within one affected family, indicates that besides the ALD gene mutations other factors strongly influence the clinical phenotype. In addition, prevention of influenza by killed viral vaccine and invasive bacterial disease by Neisseria meningitidis with multivalent polysaccharide vaccines are being used. This overview has highlighted the need to extend the evidence base for psycho-educational interventions, particularly in a UK context.

amantadine mechanism of action animation background

The role of vitamin D in the proliferation and differentiation of keratinocytes is well known within the field of dermatology. Orthodontics: a case study in the tension between guild standards and capitalism. Positive emotional style predicts resistance to illness after experimental exposure to rhinovirus or influenza a virus. We acquired ECG signals from subjects under controlled respiration in different frequencies.

amantadine for ms fatigue reviews on garcinia

To determine if use of ecstacy during pregnancy has any harmful effects on pregnancy and the (unborn) child. ovis, and protective immunity was assessed by measuring lesion areas and conducting mite counts 4 and 6 weeks later. The application allows users to display temporal trends and spatial distributions as line charts and google maps, providing a quick overview of progress in the field. In this prospective, single-center, phase II study, we compared patients treated with the Datascope Lifestick Resuscitator with patients who had been treated with mechanical precordial compression.

amantadine 100 mg concussion showtimes

Study 1 CBT participants showed significant improvement on GAD severity ratings. These side effects vary strongly in their individual expression. Verbal/performance splits in inmates assessed with the Multidimensional Aptitude Battery . The levels of various cytokines were monitored during the course and statistic analysis was performed.

amantadine drug group home

Based on these data, we propose that the C-terminus of Dr1289 has evolved in D. Hemorrhagic shock resuscitation with carbon monoxide saturated blood.

amantadine manufacturers

It is necessary to apply individual schemes of stress-limiting preoperative preparation in IHD patients. This study shows that NuMA is extensively modified following HSV infection, including phosphorylation of an unidentified site(s), and that it depends to an extent on viral DNA synthesis. Lash length was measured with a caliper at enrollment, at weekly intervals during the application of the gel, and at 1 and 3 months after discontinuation of its use.

amantadine brain injury dosage calculations

Thrombolysis has been recently reported for the treatment of unsuccessful out-of-hospital cardiopulmonary resuscitation. From these results it is suggested that the effect of exercise on the regulation of hormone on skeletal muscle may be in two directions.

amantadine stada 100 mg bijsluiter

The results of these trials vary due to different patient populations and experimental designs. An evaluation of the role of carnitine in regulating Fatty Acid oxidation and gluconeogenesis. However, in this test the assessment of the enteropathy dimension is difficult and surgical treatment should be planned with caution.

amantadine withdrawal side effects

However, concerns have been raised regarding the association between TZD use and a heightened risk for congestive heart failure (CHF). Lovastatin reduced the cytotoxic potency of doxorubicin in HUVEC.

amantadine package insert pdf in powerpoint

Modulation of neurotransmitter release probability by regulatory factors likely affects the transfer of information within the nervous system. Activation of PKA by forskolin resulted in elevated expression of the PSA gene in androgen-depleted LNCaP cells, an effect that was blocked by the antiandrogen, bicalutamide.

Testimonials
Best
 Show Hide 
amantadine uses parkinson's disease images 2014-01-04

The structure of 1 was determined to be 4-hydroxy-3-methoxybenzyl 7-methyloctanoate by spectroscopic methods. On CT, the bisoprolol sandoz 5mg filmtabletten pericholecystic fat had streaky soft tissue densities in three cases.

amantadine parkinson's tremor medication 2018-08-01

To determine whether concentrations of proinflammatory cytokines, acute-phase proteins, and cortisol differ at parturition among 3 categories of sows (noninoculated, clinically affected and nonaffected following intramammary inoculation with Escherichia coll). Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers. However, following the genital challenge no significant differences in vaginal shedding unipril 5 mg prezzo restaurant were observed between the groups immunized with the MOMP and control plasmids. The interaction between the immune and skeletal systems is evidenced by the bone loss observed in autoimmune diseases such as rheumatoid arthritis.

amantadine drug category of marijuana 2018-09-01

These two enzymes share the property of presenting two electrophoretic bands, one of which is characteristic of actively flying adult thoraces. Order-Parameter Distribution Function of Finite O(n) Symmetric Systems. Thus, for the human bronchial tree, the characteristics of air currents within the smaller branches are, ideally, conserved at the expiratory flow recorded peak action of augmentin antibiotic at the mouth.

amantadine dosage forms of adderall 2013-02-07

Interestingly, the acetyltransferase activity of p300 is important for this enhancement. The system used is composed of a PC, hardware and software (Image-Pro Plus 4.1-Media Cybernetics, U.S.A.) for image acquisition and analysis, TV camera and optical microscope. We applied Geographical Information System technology to study the geographical distribution these cases, and their associations bactoprim combi forte obat apa ya within a 50-m buffer zone spatially. Finally, the transcriptional signature of stem cells grown with FGF-2 included a large number of genes over-expressed in gliomas and a core set of conserved genes periodically expressed during the eukaryote cell cycle. Health profiles and profile-specific health expectancies of older women and men: The Netherlands.

difference between amantadine and memantine hcl 2012-07-12

This ability appears crucial for the perception of complex stimuli such as speech and is thought to reflect more central auditory processing. As magnesium is called a natural calcium antagonist, we further compared the effects of magnesium with some calcium antagonists. Previous research indicates that osteopathic manipulative treatment based on counterstrain produces a decrease in the stretch reflex of the calf muscles in subjects with Achilles tendinitis. We therefore examined cerebellum development in the zebrafish, specifically in relation to the expression of the basic helix-loop-helix gene Atonal 1, which definitively characterizes granule klerimed 500 mg alkoholtest cell precursors. We sought to develop a rapid, non-invasive method for identifying sunscreen on the skin for use in epidemiological studies.

can amantadine capsules be opened ephatha 2011-06-22

Comparative studies on intestine ultrastructure of third-stage larvae and adults of Cystidicoloides ephemeridarum (Nematoda, Cystidicolidae). HV3 described as an herbicide zovirax tablet price philippines degrader harbours the pSKY4 plasmid, encoding an aromatic meta-pathway.

mechanism of action of amantadine hcl 2010-02-17

Then, we used microdialysis to examine extracellular levels of glutamate in the PFC in response to presentation of the conditioned stimuli alone and challenge with cocaine in the presence of the conditioned stimuli. Trastuzumab (herceptin) and pertuzumab (Omnitarg, 2C4) are recombinant humanized monoclonal antibodies that target different extracellular trihexyphenidyl hydrochloride msds sheets regions of the HER-2 tyrosine kinase receptor. Regulatory mechanism of food factors in bone metabolism and prevention of osteoporosis.

amantadine stada 100 mg bijsluiter 2014-04-24

Epidemiological interpretation of antibiotic resistance studies ultop 20 tablets of amoxicillin - what are we missing? One week after the operation, ovariectomized rats were treated with 17beta-estradiol in a single administration of 4, 40, or 400 mug/kg or vehicle (placebo) intraperitoneally (IP), followed by HT or NT at 6 h after the administration.

therapeutic effects of amantadine 2012-04-28

Ten university and private medical centers in the United States. Statistical weights are assigned to residues in a helical conformation with an associated helical hydrogen bond, a helical conformation with no hydrogen bond, an N-cap position, a C-cap position, or the reference coil conformation. Gender dependent association of thrombospondin-4 A387P polymorphism with myocardial infarction. A comprehensive approach to effectively engage physicians during a hospital closure: using the physician engagement model. Complexation capacity of aquatic systems in dependence on different ligands and heavy metals - Electroanalytical keflex suspension 125mg/5ml investigations and statistical evaluation.

amantadine hcl solubility table 2018-11-03

A meta-analysis of 19 trials suggested a small increase in the risk of all-cause mortality with high-dose vitamin E supplementation. Two recent cases of intussuscepting polypoid lesions of the rectosigmoid that were successfully managed using an endo-anal approach are presented. A deficiency of PS predisposes subjects to (recurrent) venous thromboembolism (VTE) and foetal loss. To evaluate the effectiveness of transrectal ultrasound-guided permanent radioactive (125)I implantation of the prostate for organ-confined adenocarcinoma of the prostate compared with historical data of prostatectomy and external beam radiotherapy within a cooperative group setting. The frequency of amygdala theta waves ribavirin side effects without interferon also increased with in associated with P wave density.

pms amantadine hcl 2017-03-09

During ablation, a circular mapping catheter was placed in an ipsilateral PV, but the electrograms were not revealed until loss-of-pace capture. Recurrent pain following interdigital neurectomy--a plantar approach. Primary caregivers experienced moderate state anxiety and low trait anxiety. The use of the bacterial enzyme nitroreductase to activate CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) to a short lived, highly toxic DNA cross-linking agent has been demonstrated in tumor xenografts. There was no difference losiram 20 mg fiyat ikinci between the groups concerning pain at the 3- and 12-months follow-up.