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Araten (Losartan)
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Losartan

Structural basis for platelet antiaggregation by angiotensin II type 1 receptor antagonist Araten (DuP-753) via glycoprotein VI. The effects of long-term oral administration of Araten on the occurrence of stroke and on mortality were investigated in young salt-loaded stroke-prone spontaneously hypertensive rats (SHR-SPs) during the treatment period (5-20 weeks of age) and up to 8 weeks thereafter.

Other names for this medication:
Losartan, Cozaar, Lortaan, Losacar, Losakind, Lostat, Omnitan, Losium, Angilock, Angizaar, Aratan, Araten, Cardon, Cartan, Cormac, Corodin, Corus, Cosart, Covance, Eklips, Etan, Fensartan, Fortzaar, Hilos, Lacine, Lara, Larb, Lavestra, Lifezar, Loben, Logika, Loortan, Lopo, Lorista, Losa, Losacor, Losan, Losap, Losaprex, Losar, Losart, Losartanum, Losartas, Losatan, Losatrix, Lostan, Lotan, Lotar, Lotim, Lozap, Lozar, Lyosan, Mozartan, Niten, Normatens, Ocsaar, Osartil, Ostan, Prelow, Prosan, Rasertan, Rasoltan, Repace, Resilo, Rosatan, Sarilen, Sarlo, Sarvas, Sarve, Simperten, Sortal, Sortiva, Tacardia, Tozaar, Xartan, Zaart, Zartan,

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Araten is used alone or in combination with other medications to treat high blood pressure. Araten is also used to decrease the risk of stroke in people who have high blood pressure and a heart condition called left ventricular hypertrophy (enlargement of the walls of the left side of the heart). Araten may not decrease the risk of stroke in African Americans who have these conditions. This medication is also used to treat kidney disease in people who have type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood) and high blood pressure. Araten is in a class of medications called angiotensin II receptor antagonists. It works by blocking the action of certain natural substances that tighten the blood vessels, allowing the blood to flow more smoothly and the heart to pump more efficiently.

High blood pressure is a common condition, and when not treated it can cause damage to the brain, heart, blood vessels, kidneys, and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

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Mutations were made in the surface-exposed residues in the vicinity of Cys-421 and identified Arg-424 as essential for binding to Mlc. Repeated-measures models with constrained parameters for incomplete data in tumour xenograft experiments. Thereby, IL-10 limits excessive inflammatory reactions in response to endotoxin as it occurs in colitis or endotoxin shock. Subgroups having dissimilar prognoses are being identified among cancer patients with infection. Evidence for CD4-enchanced signaling through the chemokine receptor CCR5.

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As knowledge about abuse and neglect grows, clinicians are focusing on prevention as well as diagnosis and treatment. The aim of this study was to evaluate the ability of glucocorticoids to inhibit lymphocyte adhesion to human synovial fibroblasts. Data interpretation should consider numerous confounding factors such as case mix and hospital characteristics. The jet fuel jet propulsion fuel 8 (JP-8) has been shown to cause an inflammatory response in the skin, which is characterized histologically by erythema, edema, and hyperplasia.

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Timed sequential therapy of acute leukemia with flavopiridol: in vitro model for a phase I clinical trial. In fact, the deeper understanding of the origin of the observed binding free energies requires the ability to decompose these free energies to their contributions from different interactions. Our purpose was to compare the usefulness of quantitative ultrasound of calcaneus (QUS) with dual-energy x-ray absorptiometry (DXA) for identifying orthopaedic trauma patients at risk for osteoporotic fractures. Acceleration of DNA-double strand rejoining during the adaptive response of Chlamydomonas reinhardtii. Direct observations revealed that there were two morphologically distinguishable forms of cell death, which resembled apoptosis and necrosis, respectively.

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The coding sequence of the type II receptor (RII) appears to render it uniquely susceptible to DNA replication errors in the course of normal cell division. We conclude that the ipsilateral cochlear efferents may act as protectors against intense sound exposure. Strain-Direction-Dependent Growth Morphology of Vicinal Si(001) Surface. Treatment effects measured by the LSEQ corresponded to those measured for the same drugs by other assessment methods.

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Rechargeable lithium-ion batteries that use an aqueous electrolyte have been developed. Analysis of 24-hour ambulatory EEG monitoring in 315 children with paroxysmal diseases

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On the other hand, a unique phenomenon was found with the fungal hydroxylase: its NADPH-cytochrome c- or NADPH-menadione reductase activity was enhanced enormously upon binding of its substrate (fatty acid). Protein samples prepared from HeLa cells were applied to the Zn- or Cd-chelating column, and the bound proteins were analyzed by SDS-polyacrylamide gel electrophoresis followed by either silver staining, or fluorography when using radiolabel protein samples. The role of palmitoylation in functional expression of nicotinic alpha7 receptors.

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The literature is in general agreement that thrombophilia increases the risk of venous thromboembolism and adverse pregnancy outcomes, including pregnancy loss, preeclampsia, placental abruption and intrauterine growth restriction in pregnancy. Chiral capillary electrophoretic determination of the enantiomeric purity of homocamptothecin derivatives, promising antitumor topoisomerase I inhibitors, using highly sulfated CDs and fluorescence detection.

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Tropical pulmonary eosinophilia masquerading as acute bronchial asthma. The results indicated higher blood acetaldehyde and ethanol concentrations in alcoholic individuals acutely poisoned with ethanol in comparison to acutely poisoned social drinkers. MucAB was cloned into the test plasmid to enhance error-prone DNA-repair. Such vaccines need not result in sterile immunity, as is required of anti-bacterial and anti-viral vaccines. To review the literature concerning outcome measurements for cervical spondylotic myelopathy.

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Analyses through the reporter plasmid pTOPflash showed that MG132 significantly reduces Tcf transcriptional activity in the cells. In mammals, they are restricted to medullospinal areas, and little is known about their projection sites. We also stratified subjects into 20 cells for medical treatment, based on 4 age groups and 5 medical treatments.

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The type-1 receptor sorLA/LR11, a member of the Vps10p-domain receptor family that also contains domains characterizing members of the LDL (low-density lipoprotein) receptor family, has been shown to induce increased uPAR (urokinase receptor) expression as well as enhanced migration and invasion activities in smooth muscle cells in the presence of PDGF-BB (platelet-derived growth factor-BB). Despite treatment with corticosteroids, the child died at age 4 months. Activation of the human cardiac alpha-actin (HCA) promoter in skeletal muscle cells requires the integrity of DNA binding sites for the serum response factor (SRF), Sp1, and the myogenic basic helix-loop-helix (bHLH) family. Floral biology, pollen germination, and scanning electron microscopy studies have indicated different types of pollen within the same flower in at least two species of New World Lecythidaceae, subfamily Lecythidoideae.

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Other metals such as gold can induce subcutaneous sarcoma following injection, but the relevance of this observation in terms of human occupational risk is discounted. Also it can be used epidurally for postoperative analgesia and chronic pain management. Because of the great variation in the manner in which the various study parameters were reported, it was not possible to perform a reliable meta-analysis.

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Urologists must strive to learn and adapt to new technologies or risk losing them to other specialties. Correspondingly, EWS/ATF-1 expression decreased endogenous POSH expression, suggesting that six isolated genes may be involved in direct regulation by EWS/ATF-1. Medical-surgical decision-making for the treatment of polypoid lesions of the colon

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The family of enzymes responsible for the synthesis and degradation of hyaluronan are being characterized. The mean lethal frequency of aberrations increased from about 1 for diploid cells to about 2 for tetraploid cells. Although combined valve and ascending aorta replacement has been the most common surgical approach in the past, the increased cumulative risk of thrombotic and embolic events among these young patients has led to more conservative approaches.

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Here, a label-free mass spectrometric approach comparing the ion intensities of tryptic peptides was adopted, which was combined with prefractionation of whole cell lysate proteins by 1-D SDS-PAGE. In spite of the presence of an increased titer to A-protein, vaccinated fish did not demonstrate resistance to infection with atypical A. The program directors of Pediatrics, Internal Medicine, Medicine-Pediatrics, and General Surgery supported the participation of their residents. The use of o-AP substrate and amperometric detection at -250 mV (vs. The hemostasis system in the acute stage of hemolytic-uremic syndrome in children

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This paper forms an introduction to some of the issues surrounding prescreening and rescreening in cervical cytology. Our objective was to determine if cotreatment with extended-release metformin (metformin XR) can lower the threshold dose of clomiphene needed to induce ovulation in women with PCOS. Worsening on T25FW or 9HPT has a clinical impact on disability, as perceived by MS patients during daily life functioning.

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Influence of simultaneous variations in temperature and relative humidity on chemical stability of two vitamin C forms and implications for shelf life models. Polymorphisms in the genes encoding for ERalpha, ERbeta and PR did not correlate with the occurrence of uterine leiomyomas in our Caucasian population. Comparative effects of adefovir and selected nucleoside inhibitors of hepatitis B virus DNA polymerase on mitochondrial DNA in liver and skeletal muscle cells.

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To analyse the regulatory network P(tba), a representative promoter of the balhimycin gene cluster, was fused to the reporter gene egfp and integrated into the genome of A. PROGRESSIVE ASCENDING PARALYSIS IN DOGS DUE TO DEFICIENCY OF A VITAMIN B COMPLEX FACTOR FOUND IN YEAST. Neurological effects by occlusion of the carotid artery and induced hypoxia in newborn rats Combined Raman spectroscopy and transmission electron microscopy studies of a NanoBud structure. Postpartum thyroid dysfunction and the long-term risk of hypothyroidism: results from a 12-year follow-up study of women with and without postpartum thyroid dysfunction.

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Frequency selectivity, Q10, was about 2 for units with CF below 2 kHz and about 5 for those with CF above 4 kHz. The purpose of this study was to determine the prevalence of community-acquired MRSA infections in discharging ears and to compare the epidemiology of MRSA with that of other pathogens. The experience of severe events and/or major difficulties was significantly higher in patients being hospitalised for the first time than in patients who had been hospitalised several times, or in the control group. Retrograde perfusion flow was controlled to be in the range of 5.0-10.0 mL/kg/min and was gradually increased. Rocky chips and fragments larger than a millimeter are dispersed as a subordinate constituent of the debris.

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Proportion of retail cuts affected by price discounts was included in the calculations. Transcript profiling of Zea mays roots reveals gene responses to phosphate deficiency at the plant- and species-specific levels.

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Key research measures included the self-rated measurement of the impact of the death, the self-rated measurement of the duration of the reported grief, and scores on a psychiatric symptom assessment in the six months after the death. To investigate the cooperative effect of TAFB and flavonoids on blood glucose, we have studied their combined function compared with individual ingredients on enzymology, in-vitro and in-vivo. Such mapping, which depends on the direct analysis of genomic DNA, is essential for fine structural analysis and is a powerful means of verification of the order and the localization of markers: physical mapping alone, using yeast artificial chromosomes, presents some uncertainties due to the numerous chimeras and inversions that can be produced. Here, a particle comprises a rigid core and an ion-penetrable layer containing fixed charge, which mimics biocolloids and particles covered by artificial membrane layers.

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To evaluate the use of inferior vena caval filters (IVCF) prior to surgery in women with gynaecological cancer and venous thromboembolism (VTE). Additionally, dose-dependent effects of fluoxetine (0-10.0 mg/kg, IP) and d-fenfluramine (0-1.0 mg/kg, IP) on cocaine-primed (0-15.0 mg/kg, IP) reinstatement of extinguished cocaine-seeking behavior were examined. Variability at the hepatic lipase gene is also associated with interactions between intake of fat and HDL-C concentrations that could shed some light on the different abilities of certain ethnic groups to adapt to new nutritional environments. Furthermore, we observed that the deacylated ManLAMs or the lipid-free mannosylated arabinomannans, which do not exhibit characteristic ManLAM activities, do not display this supra-molecular organization. Although slight topographic changes due to oxidation were observed by atomic force microscopy, an increase in transmission due to the phase change of the metal to transparent oxide was observed.

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Exponentially growing biological and bioinformatics data sets present a challenge and an opportunity for researchers to contribute to the understanding of the genetic basis of phenotypes. Laminin P1, a pepsin-resistant fragment originating from the central portion of the cross-shaped laminin molecule, is detectable in serum and has been related to liver fibrosis and portal hypertension.

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Furthermore, the male specific expression of Cyp312a1 was universally observed in three Drosophila strains originated from the USA (Oregon R), China (Canton S), and Japan (HKJ), suggesting possible involvement of this P450 in significant endogenous catalytic reaction(s). In this paper, an efficient strategy based on two-stage analysis is proposed. Both the experimental and the Monte Carlo sensitivities agree reasonably with an analytic form that is the geometric mean of the pinhole and parallel-beam formulas, disagreeing with previous literature. We report a case of Candida albicans prosthetic valve endocarditis in a patient who was still alive 1 year following a homograft aortic root and valve replacement and antifungal therapy.

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Air pollution is associated with a variety of respiratory and cardiovascular disorders, including fibrosis. The constant number of cases along the 19 years of the study shows that Bordetella spp.

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We inserted the intraparenchymal ICP monitor within 15 minutes to 2 hours after rFVIIa administration, without waiting for the repeat coagulation results. Critical heart disease in the neonate: presentation and outcome at a tertiary care center. These data show that 21 days of restraint stress affect hippocampal corticosteroid receptors and spatial performance in a gender-specific manner. To provide clinicians with a review of important recent advances in biologic studies of the disc and their implications for potential disc therapies.

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Although such an agent has not yet been identified, an understanding of the mechanism of action and principles underlying pharmacologic thrombolysis provides the necessary foundation of knowledge to choose a particular thrombolytic agent for a given clinical scenario. Down-regulation models and modeling of testosterone production induced by recombinant human choriogonadotropin. Valproate treatment of acute alcohol hallucinosis: a double-blind, placebo-controlled study. Rat embryos explanted at gestation day 10 and cultured for 48 h in the presence of the Delta7 reductase inhibitor AY 9944 were used as a model to discriminate between the beneficial effect of supplementation with cholesterol and the deleterious effect of supplementation with 7-dehydrocholesterol.

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This work reviews the microbiologic and pharmacologic aspects of this agent in order to establish its position among the available options for antimicrobial chemotherapy. EEG power spectra revealed significant differences in the delta range of both conditions. Learning and cognitive flexibility: frontostriatal function and monoaminergic modulation. A phase I trial of oxaliplatin for intraperitoneal hyperthermic chemoperfusion for the treatment of peritoneal surface dissemination from colorectal and appendiceal cancers. Retrospective examination of 37 patients with metastatic spinal tumors treated with intraoperative radiation therapy.

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The purpose of this survey was to study child-rearing problems and necessary community welfare and health services in the families with twins or triplets as compared with families with singleton children. NAC blocked intracellular ROS formation and GSH depletion, but Z-DEVD-fmk did not. Serum total cholesterol, LDL-C, total WBC count, CRP level, TBARS, atherogenic index, activities of COX, 15 LOX in monocyte and serum myeloperoxidase were increased in cholesterol fed rats. Male ICR mice were rendered tolerant to and dependent upon pentobarbital by repeated pentobarbital administration and by abrupt pentobarbital withdrawal, respectively.

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In the home-pens, i/i birds were more feather pecked and had poorer feather condition than I/I birds. During embryonic vasculogenesis, CD24 expression is down-regulated in human embryonic stem cells. Chemical profiles of a representative set of 49 propolis ethanolic extracts collected worldwide (North and South America, Europe, Asia and Oceania) were obtained via easy ambient sonic-spray ionization mass spectrometry (EASI-MS).

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Subjects were asked to rate their preferences if faced with two scenarios: post-chemotherapy nausea and vomiting (PCNV) occurring for 3 days (scenario 1), and PCNV lasting for the rest of their lives (scenario 2). Spina bifida outpatient clinic at a university hospital in the Netherlands. This paper outlines the pathophysiologic mechanisms of the nephrotoxicity of these compounds, highlighting relevant clinical and experimental work. Levels of aerobic endurance have declined independent of BMI and deprivation.

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The models provide a natural, graphical context for browsing and visualizing complex data. A socio-psychological model based on the theory of planned behaviour is proposed to describe how these themes and underlying sub-themes relate to FSMS implementation. Adenovirus-mediated arterial gene transfer is a promising tool in the study of vascular biology and the development of vascular gene therapy. These findings provide a basis to develop risk stratification methods and targeted interventions for this population. It allowed us to directly evaluate the inside of cardiac chambers for the right ventricular outlet, great arterial root, and determine the VSD relationships.

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Further normalization of tissue architecture was indicated by (i) a slight increase in K4 extension, (ii) appearance of keratinocyte integrins beta 1 and alpha 6 in basal and parabasal cells and (iii) interruption of the band-like alpha v integrin immunolocalization at the subepithelial site. Exploratory laparotomy was performed, and a large spherical mass, which had ruptured, was found in the area of the left ovary. As a possible remedy to these problems, we conducted a preliminary study of gambling-specific cognitive-behavior therapy (CBT) with the addition of motivational enhancement techniques (MET) for the treatment of pathological gamblers. Rectal cancer margine and surgical incisal edge determined with transrectal ultrasound are close to examined by pathology.

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Three opioid receptors (ORs) are encoded by three different genes, the mu (MOR), delta (DOR) and kappa (KOR) genes in the OR gene family. In addition, it would be interesting to follow the development of their problem-solving abilities over time. Attention should be paid to the alteration of biological clock and consider it an adverse effect, when it leads to altered regulation of the circadian system which is a serious problem affecting basic functioning of living organisms. Synthesis and thrombolytic activity of carboline-3-carboxylic acid modified metabolites of Ala-Arg-Pro-Ala-Lys.

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No systematic relationship was found between cognitive change and immunological change. The specificity of the interaction of the conservative peptide H3(314-328) with monoclonal antibodies IV A1 and IV G6 was confirmed by competition RIA and by competition hemagglutinin inhibition and virus neutralization. Cutting edge: clustered AU-rich elements are the target of IL-10-mediated mRNA destabilization in mouse macrophages. Effect of particle size on molten states of starting powder and degradation of the relevant plasma-sprayed hydroxyapatite coatings. Adequate care of the lesions and preventive measures against risk factors are needed.

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Regression of dietary copper restriction-induced cardiomyopathy by copper aciclovirum uk repletion in mice. The algorithm is based on a new upper bound on the diameter of 3-permutations.

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Osteopontin (OPN) was initially identified as glycosylated phosphoprotein in bones of vertebrates. This paper discusses an expanded role for the contributions of dietitians as members of an interdisciplinary team based on research experiences in the Diabetes Control and Complications Trial, Diabetes Prevention Program and Look AHEAD (Action indomethacin pregnancy for Health in Diabetes). To characterize the vulnerability of the forebrain and midbrain cholinergic systems in PSP and CBD, we performed a comparative study of cholinergic neuronal changes in the nucleus basalis of Meynert (NBM) and the laterodorsal tegmental and pedunculopontine tegmental nuclei (LdtgN and PptgN) of brains obtained at autopsy (three cases of PSP, one case of CBD and six cases without neurological diseases) by immunohistochemistry for choline acetyltransferase (ChAT) and Gallyas-Braak staining. Microtubule-associated protein 1 light chain 3 (LC3) and Beclin 1 were also used to investigate the activation of autophagy post-TBI.

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