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Zodem (Zolpidem)

Conventional and power spectrum analysis of the effects of Zodem on sleep EEG in patients with chronic primary insomnia. At bedtime, each patient received either Zodem 10 mg, triazolam 0.25 mg, or placebo, and was allowed to sleep for a maximum of 8 hours.

Other names for this medication:
Zolpidem, Ambien, Ambiz, Lipidem, Nidra, Nitrest, Sove, Soza, Stilnoct, Zappy, Zedem, Zleep, Zodem, Zolax, Zoldem, Zolfresh, Zolip, Zolit, Zolp, Zolpi, Zolsoma, Zoltar, Zolway, Zopid,

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Zodem comes as a tablet (Ambien) and an extended-release (long-acting) tablet (Ambien CR) to take by mouth. Zodem also comes as a sublingual tablet (Edluar, Intermezzo) to place under the tongue and an oral spray (Zolpimist), which is sprayed into the mouth over the tongue. If you are taking the tablets, extended-release tablets, sublingual tablets (Edluar), or oral spray, you will take the medication as needed, not more than one time a day, immediately before bedtime. If you are taking the sublingual tablets (Intermezzo), you will take the medication as needed, not more than one time during the night if you wake up and have difficulty returning to sleep. Zodem will work faster if it is not taken with a meal or immediately after a meal. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use Zodem exactly as directed.

You will probably become very sleepy soon after you take Zodem and will remain sleepy for some time after you take the medication. Plan to go to bed right after you take Zodem tablets, extended-release tablets, sublingual tablets (Edluar), and oral spray and to stay in bed for 7 to 8 hours. Take Zodem sublingual tablets (Intermezzo) only when you are already in bed and can remain in bed for at least 4 more hours. Do not take Zodem if you will be unable to remain asleep for the required number of hours after taking the medication. If you get up too soon after taking Zodem, you may experience drowsiness and problems with memory, alertness, or coordination.

Swallow the extended-release tablets whole; do not split, chew, or crush them. Tell your doctor or pharmacist if you cannot swallow tablets.

Do not open the pouch that contains the sublingual tablet (Intermezzo) until you are ready to take the tablet. To remove the sublingual tablet (Edluar) from the blister pack, peel off the top layer of paper and push the tablet through the foil. To take either brand of sublingual tablet, place the tablet under your tongue, and wait for it to dissolve. Do not swallow the tablet whole or take the tablet with water.

To use the oral spray, follow these directions and those that appear in the package label:

  1. Before using Zodem spray for the first time, or if you have not used the spray bottle for 14 days, you must prime the pump.
  2. Line up the arrows on the cap and the base of the container. Squeeze the cap at the arrows and pull the cap and base apart to separate. Remove the clear protective cap from the pump.
  3. To prime the pump, hold the container upright. Point the black spray opening away from your face and other people. Press down on the pump with your forefinger, release and let it return to the starting position and repeat 4 more times. You should see a fine spray come out of the container.
  4. To use Zodem spray, hold the container upright with the black spray opening pointed directly into your mouth, over the top of your tongue. Press down fully on the pump to make sure that a full dose of Zodem is sprayed.
  5. Let the pump return to the starting position. If your doctor prescribed only one spray of Zodem, put the clear protective cap back over the pump at the top of the base after each use. If your doctor has prescribed two sprays of Zodem for your dose, a second spray should be used.
  6. Snap the child-resistant cap back onto the base and rotate the cap and base so that the arrows are not lined up. This is to help prevent a child from using the spray mist bottle.

Your sleep problems should improve within 7 to 10 days after you start taking Zodem. Call your doctor if your sleep problems do not improve during this time or if they get worse at any time during your treatment.

Zodem should normally be taken for short periods of time. If you take Zodem for 2 weeks or longer, Zodem may not help you sleep as well as it did when you first began to take the medication. Talk to your doctor about the risks of taking Zodem for 2 weeks or longer.

Zodem may be habit forming. Do not take a larger dose of Zodem, take it more often, or take it for a longer time than prescribed by your doctor.

Do not stop taking Zodem without talking to your doctor, especially if you have taken it for longer than 2 weeks. If you suddenly stop taking Zodem, you may develop unpleasant feelings or mood changes or you may experience other withdrawal symptoms such as shakiness, lightheadedness, stomach and muscle cramps, nausea, vomiting, sweating, flushing, tiredness, uncontrollable crying, nervousness, panic attack, difficulty falling asleep or staying asleep, uncontrollable shaking of a part of your body, and rarely, seizures.

You may have more difficulty falling asleep or staying asleep on the first night after you stop taking Zodem than you did before you started taking the medication. This is normal and usually gets better without treatment after one or two nights.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with Zodem and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website ( or the manufacturer's website to obtain the Medication Guide.

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Between 1976 and 1999, 1,649 patients with stage I or II breast cancer were treated with CS plus RT at Yale-New Haven Hospital (New Haven, CT). The best technique or combination of techniques for any given treatment will depend on the judgment and experience of the skilled clinician. IF1 inhibited ATP hydrolysis but not ATP synthesis, in contrast to angiostatin, which inhibited both. Intracerebroventricular injection of neuropeptide Y (NPY) prolonged sodium pentobarbital (PhNa)-induced sleep in rats.

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Dermatofibrosarcoma protuberans as a diagnostic pitfall in fine-needle aspiration diagnosis of angiosarcoma of the breast. In other clones, the Bd49 repeats were linked to, or interspersed with, sequences that are repetitious and distributed elsewhere on the A and B chromosomes. There is limited information on the regional inflammatory effects of mechanical ventilation and endotoxemia on the production of acute lung injury. Moreover, the transforming ability of Cot results from the coordinated activation of histone H3, which ultimately converges on the regulation of the transcriptional activity of the c-fos promoter, followed by AP-1 transactivation activity.

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Levels of Environmental Protection Agency criteria air pollutants were measured on a daily basis with concurrent monitoring of lung function, bronchodilator use, symptoms, and asthma exacerbations. The diversity of tasks that any biological recognition system must solve suggests that object recognition is not a single, general purpose process. The lateral radiograph-based system described by Tsuyama is used widely to classify ossification of the posterior longitudinal ligament (OPLL) of the cervical spine. In this retrospective analysis, 80 patients with a new diagnosis of WG, MPA or RLV with biopsy-proven renal involvement were followed over a median of 46.7 months (range: 0.8-181.9 months). We also note that, due to the geometric complexity of many bone structures--such as the skull analyzed here--load transmission paths are difficult to conceptualize a priori.

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A simple and rapid new dispersive liquid-liquid microextraction based on solidification of floating organic drop combined with inductively coupled plasma-optical emission spectrometry for preconcentration and determination of aluminium in water samples. Patients with neuromuscular diseases benefit from treatment in a warm climate. The 56 procedures in which fetal hematocrits were obtained both before and after transfusion were analyzed. We found that all three isoforms of DGK can phosphorylate 1-alkyl-2-acylglycerols but generally at a lower rate than for the corresponding diacylglycerol.

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In vitro analysis showed that IL-1 beta but not TNF was secreted from JHMV infected macrophages. PLZF was also up-regulated by androgens, at both mRNA and protein levels, in the androgen-responsive human prostate cancer cell line LNCaP. Increasing evidence suggests that secreted phospholipases A2 (sPLA2s) play an important role in the pathophysiology of atherosclerosis. Preliminary reports suggest that these drugs not only reduce available plasma glucose, but also have direct effects on cancer cell viability through modification of molecular energy-sensing pathways.

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Objectives were to assess available information on hormonal therapy for bleeding in hereditary hemorrhagic telangiectasia (HHT), to determine whether there is a role for hormonal therapy as an initial therapeutic option, and to report the second known case of response in HHT to antihormonal therapy. Ovine BST2A appears to restrict enJSRVs more efficiently than oBST2B. Using rapid-cycle quality improvement projects, this center adapted an oxygen saturation targeting protocol and tracked hourly oxygen saturation as measured by pulse oximetry in very low birth weight infants who received supplemental oxygen. The atherothrombotic samples were collected from a consecutive cohort consisting of 20 individuals admitted with STEMI to Stavanger University Hospital, Norway, from 2005-2006, presenting angiographically with an acute thrombotic occlusion of a coronary artery characterized by TIMI flow 0. We adapted the technique of Veronesi to deliver IORT prior to tumor excision to improve delivery to the region at risk and reduce the volume of normal tissue irradiated.

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Effects of environmental enrichment on behavior and dopamine transporter function in medial prefrontal cortex in adult rats prenatally treated with cocaine. To describe and quantify the endoscopic findings, survival, and predictors of mortality of elderly persons after colonoscopy. Cell cycle transition arrested at S phase and the broken DNA was noticed. These patients were treated by one ruling protocol at the Leiden University Medical Center between 1997 and 2000.

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The annual cycle of senior residents passing on the regular insulin sliding scale to first-year interns and students can be broken. Dysplastic transformation within the ileal pouch mucosa in patients operated for ulcerative proctocolitis is rare even after a long follow-up. More leadership requires more shared work, but as hospitals and medical centers begin to break down departmental barriers, people have to learn to work with individuals and groups who may have different work ethics, dissimilar styles of solving problems, or even contrasting values.

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The indications at issue are nonrheumatic chronic atrial fibrillation, mechanical and biological heart valve prostheses, coronary artery disease, coronary stents and peripheral arterial occlusive disease. Surgery may be indicated only for carefully selected T4N0M0 patients with or without neoadjuvant chemotherapy or chemoradiotherapy.

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Expression of a developmentally-regulated neuron-specific isoform of the neurofibromatosis 1 (NF1) gene. Localization of these NOS isoforms in the lung and their functional roles are discussed. Effectiveness and safety of 5-azacitidine in three patients with myelodysplastic syndromes Differences in the response of serum lipoproteins to fenofibrate between women and men with primary hypercholesterolaemia. All patients filled in the Chronic Fatigue Syndrome Activities and Participation Questionnaire (CFS-APQ) and performed a maximal exercise stress test on a bicycle ergometer.

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Mx1Cre mice were crossed with a reporter strain (ROSA26tm1Sor) in which beta-galactosidase activity is expressed only after Cre-mediated recombination to determine the cellular pattern of Cre-mediated genetic recombination in the kidney and other tissues. Liver transplantation (LTX) today has become a routine procedure granting curative treatment for various hepatic diseases with excellent survival rates. Continence was defined as no pads or one diaper/24h and was assessed 3, 30, and 90 d after the procedure. Several FRQ- and WC-independent, noncircadian FRQ-less oscillators (FLOs) have been described, each of which appears to regulate aspects of Neurospora growth or development. Thallium-201/ Tc-99m pertechnetate imaging yielded eight true-positive, four false-negative, and two nondiagnostic studies because of lack of Tc-99m pertechnetate uptake from thyroid hormone suppression.

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This case report describes the clinical, radiologic, and histopathologic features of the glandular odontogenic cyst (GOC). Region-specific alterations of global protein expression in the remodelled rat myocardium. Comparison of the antimicrobial efficacy of irrigation using the EndoVac to endodontic needle delivery.

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In an 8-year follow-up study for 145 dementia outpatients the survival and relative death risks (hazard ratios) were calculated with Kaplan Meier and Cox-regression analyses. The management of respiratory motion in radiation oncology report of AAPM Task Group 76. The second part is dedicated to experimental measurements on the skin in vivo. All 224,101 TB cases reported to the US National Tuberculosis Surveillance System from the 50 states and the District of Columbia from 1993 to 2004 were included.

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Differential gene expression in human cerebrovascular malformations. The aim of our study was to identify the prevalence of this single nucleotide polymorphism (SNP) in chondrosarcoma patients, to determine its correlation with disease outcome, and to discern whether it could serve as a prognostic marker in patients with chondrosarcoma. Complex study of the feto-placental system and therapeutic tactics in intrauterine fetal growth retardation The study aimed at assessing functional state of vessel endothelium using Doppler cardiography in patients with arterial hypertension and excessive weight under Nebivolol treatment.

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The most resistant daughter cell line, RPMI8322/CDDP-300, was 4-fold resistant to cisplatin, and partially cross-resistant to carboplatin, melphalan and UV, but not to BCNU. These acute effects of cocaine were hardly affected by co-administration of the sigma receptor antagonists, except that BMY-14802 enhanced, but not significantly cocaine-induced locomotion. Pregnancy complicated by the antiphospholipid syndrome: outcomes with intravenous immunoglobulin therapy.

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The decrease in HDL-cholesterol in the diabetic patients was inversely proportional to waist circumference, waist hip ratio, and body mass index (BMI). Using a modified subtractive hybridization, we identified PLZF as an androgen-responsive gene in the rat ventral prostate. The patho-anatomic specimen also showed aberrant bands and false tendons, a frequent finding in hearts with LVHT. As the interaction of NT3 and TrkA temporally and spatially precedes the interaction of NGF with TrkA, we examined the signaling of NT3 in a CIPA-associated TrkA mutant. The first kappa-agonists to be developed were brain-penetrating organic small molecules.

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Microtensile bond strength of self-adhesive luting cements to ceramic. This has led to the development of sensitive confocal micro-Raman spectrometers and imaging spectrometers that are capable of obtaining high spatial-resolution spectra and images of subcellular components within single living cells. solfataricus thioredoxin reductase constitute a new thioredoxin system in aerobic thermophilic archaea. MtDNA depletion, over-replication, and multiple deletions were found in further 11 cases.

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In this study, index patients from each of 14 Danish FH families amiodarone pulmonary toxicity mechanism design were screened for mutations in exon 2 of the LDLR gene using a denaturing gradient gel electrophoresis (DGGE)-based mutation screening assay. Whereas oral tolerance therapy may be both simple and effective, the requirement for large amounts of protein will limit clinical testing of autoantigens, which are difficult to produce. Human embryonic stem cells: prospects for human health - a 1-day international symposium held at the University of Sheffield. We concluded that OPN plays a crucial role in the morphological conversion of calcium oxalate crystals to stones in mouse kidneys.

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A 1-year diabetes fellowship is a replicable solution to address the need for diabetes care specialists. Protein profiles of Mycobacterium vanbaalenii PYR-1 grown in the trevilor 75 mg retirement presence of high-molecular-weight polycyclic aromatic hydrocarbons (HMW PAHs) were examined by two-dimensional gel electrophoresis (2-DE). A series of subunit chimaeras containing alpha 7 and 5-HT(3A) subunit domains have been constructed and expressed in cultured mammalian cells.

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AT1 receptor in rostral ventrolateral medulla mediating blunted baroreceptor reflex in spontaneously hypertensive rats. We conducted a case-control study to identify risk factors for hemorrhage following CABG surgery and a historical cohort study to quantify outcomes of hemorrhage. Cardiovascular risk factors clindamycin dose renal failure include independent factors such as advanced age, male gender, family history and modifiable risk factors including cigarette smoking, arterial hypertension, lipid disturbances, diabetes mellitus, obesity, dietary habits and stress. Fistula function before and after intervention was assessed with ultrasound dilution technique. To evaluate the correlation between assessment of postvoid residual urine by transabdominal ultrasound and catheterization in patients after radical or transvaginal hysterectomy.

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The role of lymphatics in removing pleural liquid in discrete hydrothorax. In conclusion, rapamycin has the potential to significantly reduce the B and T cell responses and thereby protect from glomerulonephritis when administered early in disease. Determination of gold in geological sample by inductively coupled plasma mass spectrometry after carbon nanofibers separation and preconcentration Expression and subcellular maximum dosage procyclidine hydrochloride distribution of glutamate receptor subunits 2/3 in the developing cerebellar cortex.

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