on all orders above $300.00

FREE Pills!


for free with every order



Less than in your
local pharmacy

Search by letter:


Enter coupon: (if you have one)

Digene (Pantoprazole)

Digene is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Digene is used to treat erosive esophagitis (damage to the esophagus from stomach acid caused by gastroesophageal reflux disease, or GERD) in adults and children who are at least 5 years old. Digene is usually given for up to 8 weeks at a time while your esophagus heals. Digene is also used to treat Zollinger-Ellison syndrome and other conditions involving excess stomach acid.

Other names for this medication:
Pantoprazole, Protonix, Aciban, Acipan, Anagastra, Anesteloc, Apazol, Apton, Caprol, Ciproton, Contix, Contracid, Controloc, Digene, Eupantol, Gastromax, Gastrowell, Noacid, Nolpaza, Ozepran, Pandev, Pandon, Panpac, Pansec, Pantac, Pantaz, Pantecta, Pantin, Pantium, Pantoc, Pantocal, Pantocalm, Pantocid, Pantodac, Pantor, Pantorc, Pantosec, Pantozol, Pantpas, Pantul, Pantus, Panum, Panzo, Panzol, Pentalink, Pents, Peptac, Peptazol, Pepzol, Prazolan, Progen, Tecta, Tonval, Topra, Topraz, Topzole, Trupan, Ulcemex, Ulcepraz, Ulcoreks, Ulcotenal, Unigastrozol, Zacpac, Zepoxin, Zimpax, Zipant, Zipantola, Ziprol, Zovanta, Zurcal, Zurcazol,

Similar Products:
Mevilox, Bludol, Nucoxia, Uritracin, Daonil, Blistex, Pioner, Mitil, Medoclav, Kepinol, Fenoglide, Tarden, Nortriptyline, Neurontin, Rexan, Klavax, Abamune, Barole, Beclabuvir, Amoxistad, Lunesta, Trevilor, Ramigamma, Paxum, Grisetin, Gabapen, Amigrenex, Uricont, Osyrol, Akarin, Klomifen, Esram, Noloten, Protop, Lamez, Tefilin, Dolex, Klarimac, Aviral, Acuzole, Lopid, Metazol, Nebivolol, Nicord, Lamictin, Clopes, Cliofar, Methacin, Entizol, Vals,

Digene is used to treat certain stomach and esophagus problems (such as acid reflux). It works by decreasing the amount of acid your stomach makes. This medication relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. It helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus. Digene belongs to a class of drugs known as proton pump inhibitors (PPIs). OTHER This section contains uses of this drug that are not listed in the approved US professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. This medication may also be used to treat and prevent stomach and intestinal ulcers.

digene tablet contents page

Structural determination and tryptophan fluorescence of heterokaryon incompatibility C2 protein (HET-C2), a fungal glycolipid transfer protein (GLTP), provide novel insights into glycolipid specificity and membrane interaction by the GLTP fold. Anticancer activity of isoobtusilactone A from Cinnamomum kotoense: involvement of apoptosis, cell-cycle dysregulation, mitochondria regulation, and reactive oxygen species. Profuse epistaxis following sphenoid surgery: a ruptured carotid artery pseudoaneurysm and its management. To understand whether radiologists are sufficiently aware of the incidence, impact and risk factors of CIN, and whether they are taking sufficient measures to prevent CIN among patients undergoing CT. Intriguingly, the interaction between Orc1 and Cdc6 is disrupted when the cdc6(K114E) protein is used.

digene gel mint

Electrophysiological evaluation of the stiff-man syndrome: further data. The author explains the process by which this uncivil behavior may increase which can lead to more violent forms of work place strife.

digene gel doesn't

The efficacy and safety of cefovecin in the treatment of feline abscesses and infected wounds. Potential explanations for the educational gradient in coronary heart disease: a population-based case-control study of Swedish women. To serve patients, BCI systems must become safe, reliable, cosmetically acceptable, quickly mastered with minimal ongoing technical support, and highly accurate even in the face of mental distractions and the uncontrolled environment beyond a laboratory. To evaluate the effect of a visual field test educational video on the reliability of the first automated visual field test of new patients. By day 5, post-hatch, hypothalamic 5-HT content was higher in males than in females.

digene gel syrup dosage form

Our results suggest that the ability of the HPV-1 E1 protein to initiate DNA replication in vivo in the absence of the E2 protein may be due to its stable interaction with the HPV-1 origin. The differences were significant after days 4 and 7 for 0.01-mg/kg and 0.1-mg/kg doses, respectively. The results obtained confirm also the difference in reactivity of rabbit vessels from two vascular beds to vasoconstrictive agents under hypoxia. Peripheral arterial tonometry for risk stratification in men with coronary artery disease.

hybrid capture 2 hpv dna testing digene tablets

Sex-determining genes on mouse autosomes identified by linkage analysis of C57BL/6J-YPOS sex reversal. The best stimulating source is that which results in maximum gain and minimum variability of the response, especially if high apparent velocity is used, since in this condition, neither of the two systems is capable of ensuring maximal gain. They encoded AGL11, a MADS box transcription factor known to be expressed in the carpel and ovules, and a novel Arabidopsis endo-1,4-beta-D-glucanase (ATCEL2).

digene gel nails

The following were assessed: presenting symptoms, general context, bacteriological analysis, imaging protocol sensitivity, complications, delay to healing, and cure rate. Acrylamide is a synthetic monomer with a wide scope of industrial applications, mainly as a precursor in the production of several polymers, such as polyacrylamide.

digene fast melt allergy

Oxcarbazepine (OXC) plasma levels were measured over a period of 24 h from dosing, using a sensitive HPLC method. This paper investigates exponential synchronization of coupled networks with hybrid coupling, which is composed of constant coupling and discrete-delay coupling. No cross reactivity with other plant virus similar to potato virus Y, lettuce mosaic virus and tomato ring spot virus were found.

digene gel drugs

In Experiment 2, priming was also found for preexperimentally unfamiliar faces which were familiarized during the experimental session. Melain G, a cysteine protease from green fruits of the bead tree, Melia azedarach: a protease affected by specific amino acids at P3 position. Discarded extended-wear contact lenses were collected from patients with no ocular surface disease.

digene syrup benefits of coconut

In the former two systems the stabilized species is the thiyl radical, formed by initial loss of an electron at some of the guanines in the crystal lattice, followed by hole migration to thioguanine and subsequent deprotonation of the radical formed. New scientific models have been established in the past few years to identify novel factors of hemostasis and thrombosis and to analyze their function in greater detail. Our recent results indicate that coupling between AII cells and cone bipolar cells forms an obligatory synapse for transmission of scotopic visual signals to on-center ganglion cells. Responses of cerebral arterioles to ADP: eNOS-dependent and eNOS-independent mechanisms. Here we have used primary cortical cells from rat embryos to demonstrate that this compound is also neuroprotective against the toxic effects caused by the prion agent PrPSc and lead acetate (Pb).

digene medicine pregnancy cold

To characterise and investigate patients diagnosed with murine typhus in the Waikato District Health Board (DHB) region during 2006. An 18-year follow-up of primary hepatic carcinoid with carcinoid syndrome. All those aged 65 and over in the least active four fifths of the population responding to a baseline survey. We identified a mouse gene (designated Rce1) that shares sequence homology with a yeast gene (RCE1) implicated in the proteolytic processing of Ras2p. Polypeptide growth factors are positive and negative regulators of prostatic growth and function, and many positive regulators of growth in the prostate have been extensively studied.

digene syrup for acidity

A changing relation between the PR interval and the fetal heart rate is of potential use in the detection of fetal compromise. The regulation of trichothecene biosynthesis by the ambient pH appears to be a general mechanism, independent of strain or chemotype, as all tested strains, including F. T20-310 was a multicenter, open-label, nonrandomized, noncomparative study of the safety and efficacy of 2.0 mg/kg (maximum 90 mg) twice-daily subcutaneous enfuvirtide for 48 weeks in 52 treatment-experienced, HIV-1-infected pediatric patients (3-16 years) receiving optimized background therapy.

digene tab composition

An historical cohort study of consecutive unselected admissions with AMI identified using the Hospital In Patient Enquiry (HIPE) database and validated according to MONICA criteria for definite or probable AMI. Owing to the peculiar biochemical properties of small RNA molecules, the actual therapeutic translation of findings in vitro or in cell cultures is more demanding than with small molecule drugs or proteins. The common polymorphism V34L yields a FXIII that is more easily activated than the wild type enzyme. Training in large bowel cancer surgery: observations from three prospective regional United Kingdom audits. This prospective study involved 2,000 menopaused women aged 50 years or more.

digene hpv test fda approval

Elevated plasma leptin levels may be an independent risk factor for the development of cardiovascular disease. Formulation of therapeutic synthetic polymers for drug and gene delivery. These results indicate that the beta2AR is involved in the down-regulation of human H1R by inhibiting H1R gene transcription through a PKA-dependent process. The objective of this study was to investigate the extent to which previous primary care consultation and self reported health status are predictors of future primary care consultation. Few sources for these radicals have been identified but experimentally activated neutrophils are known to release free radical which contribute to myocyte necrosis.

digene syrup benefits

Temporal trends in the use of drug-eluting stents for approved and off-label indications: a longitudinal analysis of a large multicenter percutaneous coronary intervention registry. A quantitative single-group, within-subjects repeated-measure design was used to investigate the relationship between the variables following incentive spirometry. GaAs/AlGaAs nanowire heterostructures studied by scanning tunneling microscopy.

digene hc2 hpv dna test fda approval

As for the control cohort, the decreasing tendency of UDS index with age was found. Gold nanoparticle/polyaniline nanotube membranes on the glassy carbon electrode (Au/nanoPAN/GCE) were constructed for the electrochemical sensing of the immobilization and hybridization of DNA.

digene tablet purposes

Discrepancies between clinical and surgical--pathologic staging of cervical carcinoma Overexpression of D-type cyclins, E2F-1, SV40 large T antigen and HPV16 E7 rescue cell cycle arrest of tsBN462 cells caused by the CCG1/TAF(II)250 mutation.

digene gelusil syrup

  • digene gel flavors of entanglement
  • digene tablet content
  • digene gel use
  • digene gel contents interiors
  • digene chewable antacid tablet
  • digene gel syrup dosage
  • digene tablet contents of pandora's box
  • digene tablet before or after food
  • digene tablet benefits of honey
  • digene powder valley
  • digene gel used for ultrasound
  • digene gel label
  • digene antacid in pregnancy
  • digene liquid
  • digene tablet benefits of wheatgrass
  • voor degene of digene medicine
  • digene gel flavors of jello
  • digene tablet benefits
  • digene gel composition
  • digene liquid glass
  • digene tablet before or after foods
  • digene syrup usage of water
  • digene tablets india
  • digene syrup usage of computer
  • digene gel contents of cigarettes
  • digene tablet expiry date
  • digene tablet user
  • digene syrup wikipedia
  • digene gel dose of colors
  • digene tablet for gas
  • digene tablet contents of the dead
  • digene gel contents of a business
  • digene tablet dose
  • digene gel in pregnancy
  • digene tube
  • digene antacid dosage for gerd
  • digene gel flavorus customer
  • digene tablet price in india
  • digene gel contents of the dead
  • cervista vs digene hpv
  • digene antacid pregnancy safe
  • digene syrup contents of pandora's box
  • digene hc2 fda
  • what is digene syrup
  • digene tablet dosages
  • digene syrup contents definition
  • digene gelusil reviews
  • digene gelusil tablet
  • digene hc2 fda jobs
  • digene medicine pregnancy nausea
  • digene gelusil during pregnancy
  • digene gel contents of first aid
  • digene syrup usage meter
  • digene syrup usage
  • digene tablet contains definition
  • digene tablet contents definition
  • digene us agencies auto insurance
  • digene tablets
  • digene syrup us agency
  • digene gel during breastfeeding milk
  • hybrid capture ii digene tablets
  • digene gelusil liquid
  • digene hpv test canada
  • digene syrup side effects
  • digene medicine composition
  • digene tablet contents of first aid
  • digene gel
  • digene syrup dose
  • digene gel flavors
  • digene tablet contains hemoglobin
  • digene syrup contents by allegro
  • digene liquid metal
  • digene antacid side effects
  • digene gel doesn't
  • digene tablet usage agreement
  • digene gel flavorus reviews
  • hybrid capture 2 hpv dna testing digene tablets
  • digene syrup benefits of probiotics

digene gel used for knee

Practical improvements to the convolution/superposition method are suggested. Efficiency considerations for the purely tapered interference fit (TIF) abutments used in dental implants. Here, we show that the LD is involved in the production of infectious virus particles. An innovative optimised method, including an experiment and a mathematical model, for the calibration of the force platform location in the optoelectronic reference frame is proposed.

digene gel mint

The development of specific receptor antagonists, especially dopamine and serotonin, has broadened and strengthened the options available for the treatment of nausea and vomiting. The resulting higher level of receptor activation by EGF, however, did not yield higher levels of phosphatidylinositol (4,5)-bisphosphate (PIP2) hydrolysis over those stimulated by TGFalpha. On the other hand, intravenous injections of the alpha-agonist metaraminol (5 microg) slightly decreased the release of NA in the PVN area that accompanied an elevation in MAP.

digene medicine wikipedia

Skeletal cells synthesize IGF I and II and the six known IGF binding proteins (IGFBP). Our findings suggest that citizen participants are highly critical of, and discerning about,their public participation experiences. Induction of cementogenesis by recombinant human osteogenic protein-1 (hop-1/bmp-7) in the baboon (Papio ursinus). Superoxide production and LDL oxidation by diabetic neutrophils. Other differentially active PS4 identical with targets, such as electron transfer flavoprotein alpha, protein disulfide isomerase A5, and nuclear distribution gene C homolog, constitute novel proteins that potentially mediate HCV propagation.

cervista vs digene

Other outcome measures included rate of minor adverse events, cardiologist assessment of case preparation and presentation, patient satisfaction and duration of pre-admission clinic. Significant correlations of the SMFA-D indices with the SF-36 and WOMAC scales preoperatively could be shown.

digene tablet contents of the ark

We report a case with adult respiratory distress syndrome (ARDS) associated with increased levels of squamous cell carcinoma-related antigen (SCC) in the serum and bronchoalveolar lavage fluid (BALF). It accurately reproduced the kinetics of the therapeutic reduction of PSA and predicted the future nadir level correctly. The number of odontoblasts in the mandibular incisors, an index of incisor development, increased more than that of the maxillary incisors with increase in fetal body weights.

digene antacid dosage for kids

A Bernoulli statistical model was constructed to describe the probability of STI infection. Administration of 100 mg kg(-1) l-arginine for 7 days either before or after alloxan injection significantly ameliorated the oxidative stress evidenced by a lower TBARS and a higher level of the endogenous GSH concentration and SOD and CAT activities than alloxan-treated rats. Although there are similarities between this form of arthritis and the more common rheumatoid or degenerative arthritis, this particular entity is unique, and physicians or surgeons treating these patients should be aware of the differences to advise or carry out appropriate treatment. In 1986, a new technique using lead oxide was proposed, which permitted very high-quality imaging and rapidly became the technique of choice, despite its high toxicity. The cascade intermolecular arylation, incorporated in this transformation, allowed for efficient synthesis of fully-substituted fluorenes 12.

digene gelusil syrup

Comparison of colonoscopy and fecal occult blood testing as a first-line screening of colonic lesions in patients with newly diagnosed acromegaly. As such, it also plays an important role in numerous approaches to the engineering of human tissues for medical applications related to tissue, bone, and skin repair and reconstruction. The skull size was classified into the following three clusters of localities from the matrix of Q-mode correlation coefficients: 1) Langkawi and Tenasserim, 2) Laos and Thailand, 3) Sumatra and Borneo.

digene hpv test package insert

I focus particularly on the pre-puberty period (from 7 to 9 years), a period in which the existential drama surfaces and in which the bulwarks against anxiety are constructed. No significant difference in locomotor performances or in muscle fibre type conversion was found between trained and untrained mice.

digene medicine wiki

Demonstration of a different sensitivity to epinephrine in isolated and in vivo hearts. Normal fasting plasma glucose and risk of type 2 diabetes diagnosis.

digene fizz powder drink

Colic is a multifactorial disorder that appears to be induced by environmental factors and possibly a genetic predisposition. Cultural factors may significantly influence subjective assessment scales such as the self-administered hand symptom diagram, which has been found effective in North American populations. Results have been hampered by frequent rejection episodes as well as technical and infectious complications.

digene tablet usage statistics

Haploid loss of p53 overcame embryonic senescence but failed to prevent the adult mutant mice from prematurely aging, which included decreased life span, reduced body fat deposition, osteoporosis, skin atrophy, and decreased wound healing. In single channel recordings from excised nuclear patches of cells expressing IP(3)R2, cAMP alone had no effect, but it increased the open probability of IP(3)R2 activated by a submaximal concentration of IP(3) alone or in combination with a maximally effective concentration of ATP. Significance of autoimmunity to non-desmoglein targets in pemphigus. We discuss the importance of advance care planning, provider-patient communication, and appropriate palliative care and hospice referral for frail older adults. Teenagers with better knowledge, who rated their school sex education as effective, who were comfortable talking about sex and who had discussed contraception with peers were more likely to have used services.

digene tablet contents of a resume

It discusses the indications and contraindications for radiotherapy. PCR analysis and DNA dot-blotting hybridization assay indicated that the HN gene had inserted into the FPV genomic DNA. A newly identified immunodominant membrane protein (pMB67) involved in Mycoplasma bovis surface antigenic variation.

digene antacid pregnancy safe

We compared the growth of 28 hypogonadal thalassemic patients in whom puberty was induced to that of 25 patients in whom puberty occurred spontaneously. Hyperventilation and photic stimulation were performed according to the standard protocol of IPS. Several key learnings are discussed, especially in areas such as health human resources, funding, liability, regulation, information and communication technologies, management and leadership and planning and evaluation.

digene liquid marijuana

Bioequivalence assessment: a pharmaceutical industry perspective. This is a case of a 74-year-old male with known multiple peripheral aneurysms. Understanding the genetic basis of this complex autoantigen-autoantibody system will provide insight into the pathogenesis of lupus in mice, which may have implications for human disease. Induction and subcellular localization of two major stress proteins in response to copper in the fathead minnow Pimephales promelas.

digene india medicine

Antibodies to constituents of the cytoplasmic (nup180) and nucleoplasmic (nup153) filaments extending from both sides of nuclear pore complexes also stained the AL, indicating that pore complexes are intrinsically asymmetric assemblies independent of their specific intracellular topology. The statins have demonstrated growth inhibitory activity in cancer cell lines and preclinical tumor models in animals. Preparation of immobilized penicillin V acylase from Fusarium oxysporum and its properties Myositis ossificans circumscripta (MOC) is a rare benign disorder characterized by heterotopic ossification of soft tissues. The microsatellite instability status was significantly associated with MUC6 expression.

digene tablet benefits

High depressive scores were associated with female gender, and region of origin amongst the UASC. Intraperitoneal TAK-147 injection ameliorated scopolamine-induced deficit in a dose-related manner. 0.2kb promoter sequence of the murine Cyp19 gene target beta-galactosidase expression to specific brain areas of transgenic mice.

digene gel flavorus

We find that front dynamics in a highly nonadiabatic (slow front) limit is controlled by fixed points of the reduced dynamical equations, that occur close to the boundary. The reduced toxicity of etoricoxib (less faecal blood loss and fewer endoscopically detectable lesions) suggests that use of this drug will may be associated with a reduced incidence of gastrointestinal perforations, ulcers and bleeds. The purpose of this article is to review the literature on the ability of individuals with dementia to drive an automobile. In the first step the resin is placed in the cylindrical cavity with a metal pin embedded in the middle of the composite restoration. At 2.5 fibrils/cc, the lungs had normal alveolar architecture with a few dust-laden macrophages (dust cell response) in the alveolar airspaces.

 Show Hide 
digene powder movie 2012-06-05

The extended list of these endogenous inhibitors of NF-kappaB may provide new opportunities for the development of novel strategies for the intervention of malignant transformation. However, one patient had to have gas reinjected and in another subretinal fluid persisted for 3 months. The stable expression of levofloxacin price in pakistan lt600 Delta C-LyGDI induced pulmonary metastasis in 1-1ras1000 cells, whereas expression of full-length LyGDI did not induce metastasis. Resected tumor tissues were stained with metallothionein monoclonal antibody E9.

digene gel contents of a dead 2019-11-11

While MIF up-regulation in the bladder was increased with substance P treatment, it was only prevented by intravesical lidocaine. Even though dangerous, a step-wise exposure test was necessary to allow safe treatment of active pulmonary TB. Epigenetics mims indonesia metronidazole and alcohol in Apicomplexa: control of gene expression during cell cycle progression, differentiation and antigenic variation.

digene gelish gel 2011-12-02

Some uric acid stones contained calcium oxalate stones (whewellite or weddellite) as a nucleus. The HPA 1a negative women were screened for anti-HPA 1a antibodies. Regulation of soybean nodulation independent of ethylene signaling This study aimed to identify genes regulated by IL-11 during decidualization in mouse uterus, and to examine cefdinir dosing information for zoloft their expression and localization as an indication of functional significance during early pregnancy.

digene in usa 2011-03-30

herbarum hydrophobin represents the first component of the cell wall of fungi demonstrated to act as a rare but clinically relevant allergen in vitro and in vivo. The rabbits were allocated to three groups: meloxicam 15 mg tablet for pain a control group, one with oesophageal varices and one with varices which were treated by sclerotherapy.

digene hpv test qiagen usa 2018-02-20

Some ectothermic animals are subject to changes of body temperature during routine activity. Comparison between predicted and actual dose distribution in interstitial therapy of the oral cavity. Repeat percutaneous tracheostomy in the neurocritically ill patient. Reduction of brain noise influence in evoked neuromagnetic source localization using noise spatial correlation. A study of the analytical behaviour of selected synthetic and naturally occurring quinolines using electrospray ionisation ion trap mass spectrometry, liquid chromatography actinoplanes utahensis acarbose brand and gas chromatography and the construction of an appropriate database for quinoline characterisation.

digene medicine pregnancy cold 2011-08-16

Here we report the isolation of a gene and a gene fragment from the kinetoplastid Trypanosoma rangeli which encode products related in sequence to the trans-sialidase enzyme of T. NT-proBNP: a marker for successful myocardial reperfusion maprotiline hydrochloride and imipramine in AMI patients treated with primary percutaneous coronary intervention. Substrate effects on the SERS activity at single particle level were evaluated by a comparative study of the Raman images of Au, Au/Ag, and Au/Pt MFs.

digene chewable antacid tablet 2014-03-02

In addition, in vivo functional tests show that the SpEts4 cis element confers nonvegetal transcription of a beta-galactosidase reporter gene containing the SpHE basal promoter, and provide strong evidence that the activity of this transcription factor is an integral component of the nonvegetal transcriptional regulatory apparatus, which is proximal to, or part of, the mechanism that establishes the animal-vegetal axis of the sea urchin embryo. To investigate the distribution and clinical manifestations of intracranial arterial occlusive citrato de sildenafila eurofarma 50 mg benadryl lesions (IAOLs), and their correlation with thyroid function.

digene syrup benefits of wheatgrass 2018-11-27

Inactivation of the von Hippel-Lindau (VHL) gene is associated with the development of highly vascularized tumors. She obat ciprofloxacin 500 mg was then treated with an allogeneic peripheral blood stem-cell transplant that led to complete resolution of her disease. Hyperoxia reversed hypercarbia-induced vasodilation in RA in a concentration-dependent manner. The Future of Emergency Care in the United States Health System: an Institute of Medicine report.

digene syrup contents interiors 2011-01-28

This effect of acetylcholine on the membrane potential was not observed when the drug had a positive chronotropic effect. The most common presentation is a mass of the abdominal wall associated with pain during menstruation. The present values may be used to help in counselling British patients before radical prostatectomy. We evaluated the yield of rhTSH stimulation in three groups of patients, classified according to the UICC/TNM risk stratification and the results of first follow-up testing. Interleukin-1beta-mediated inhibition of the linagliptin renal dose bactrim processes of angiogenesis in cardiac microvascular endothelial cells.

digene tablet wikipedia 2015-08-29

The biochemical measures of liver injury that characterize viral hepatitis due to hepatitis C were followed prospectively in 84 individuals treated with alpha-Interferon. Afterwards we examined their acceptance in cooperation with the Department for Interdisciplinary Quality Management. Medication use was recorded for one hundred two patients who openvas vs nessus vs nexpose presented with dizziness.