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Edex (Alprostadil)

Edex is produced endogenously and causes vasodilation by means of a direct effect on vascular and ductus arteriosus (DA) smooth muscle, preventing or reversing the functional closure of the DA that occurs shortly after birth. This results in increased pulmonary or systemic blood flow in infants. In infants, it is used for palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. In adults, it is used for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.

Other names for this medication:
Alprostadil, Caverject, Edex, Vitaros,

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This medication is used to treat male sexual function problems (erectile dysfunction). It works by helping the blood flow into the penis to achieve and maintain an erection. This medication is not for use in women or children. This medication is not recommended for use in men with penile implants.

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Fluorescence and transmission electron microscopy demonstrated that the DMAB coated cationic nanoparticles were able to evade the endosomal lumen and localise in the cytosol of treated cells. An epizootic infection of Citrobacter freundii in a guineapig colony: short communication. Ascochytatin, a novel bioactive spirodioxynaphthalene metabolite produced by the marine-derived fungus, Ascochyta sp.

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A 66-year-old woman rapidly developed a typical opsoclonus-myoclonus syndrome within a few hours, presenting vertigo, cerebellous ataxia, multidirectional involuntary ocular movements and non-rhythmic axial and segmentary myoclonia. To this aim, somatosensory evoked potentials were evoked by intra-epidermal electrical stimulation and recorded from the scalp in 8 beagle dogs. Here, we review recent advances in understanding how ensembles of mitotic proteins coordinate spindle assembly and chromosome motion in this system. Persistent bone marrow edema-like signal intensity in MRI is frequently found in patients after OCT and may post-operatively continue for years without significant relation to delamination and loss of the graft and knee pain.

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We cultured the gullets of 20 medicinal leeches to re-examine the antibiotic sensitivities of Aeromonas hydrophila, the leech enteric organism associated with reported infections. Here we showed expression of VEGFRs and NRPs on cultured epidermal keratinocytes at both mRNA and protein levels. In embryonic skeletal and cardiac muscle, which also express BCK, the same compartmentation of BCK was seen, with BCK localized primarily in the cell nucleus of cardiac and skeletal myoblasts.

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Tri-Port-NOS-SIG offers a feasible scarless approach for abdominal resections using commercially available surgical instruments in experienced hands. Anxiety often remains unrecognized or untreated among patients with a chronic illness.

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In three repeated PCRs, the results were inconsistent in three samples. We analyzed the involvement of these pathways in the regulation of E-cadherin-dependent cell-cell adhesion by gastrin, a mitogenic factor for gastrointestinal (GI) tract. A 17 year-old man presented with hypersomnolence one week before admission.

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This study demonstrated that URSL achieved excellent results for upper ureteral calculi greater than 1 cm. The extracts were chromatographed on a reversed-phase mu Bondapak C18 column using methanol-50 mM KH2PO4 (pH 4.0) (30:70, v/v) as the mobile phase at a flow-rate of 1.0 ml/min. Here we find that three CDKIs, flavopiridol, purvalanol A, and methoxy-roscovitine, block Moloney murine leukemia virus (MLV) transcription events. The pamphlet scored a reading ease grade of 45, corresponding to what is considered difficult reading and at a level commonly found in academic journals. New dual electrochemical detector for microbore liquid chromatography.

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The localization of CAR to these important junctional complexes suggests that CAR may play both a structural and a regulatory role in skeletal and cardiac muscle, and that these complexes may serve as a point of entry for Coxsackie B virus. Additionally, these studies demonstrate increased plasma DNP-LI in human CHF. A large proportion of the (oo)cyst containing samples were selected for molecular characterization.

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Furthermore, recombinant HS1 binds directly to Arp2/3 complex with an equilibrium dissociation constant (K(d)) of 880 nM. The results showed: there were no major differences in the perinatal and neonatal characteristics between the two groups, consistently higher IgG levels were found in the IVIG group, and the age of first documented sepsis was earlier in the control group.

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Treatment of obstructive sleep apnea by continuous positive airway pressure: new options Myocardium from autoimmune heart, but not the normal forms, specifically increased phosphoinositide turnover in the presence of histaminergic agonists. Corrected QT intervals were significantly prolonged in patients with subclinical hypothyroidism. The signals were recorded in a magnetically shielded room while the subject was sitting under a whole-scalp neuromagnetometer and were averaged time-locked to the R wave of the electrocardiogram. This one is considered as the main generator of necroticoinflammatory lesions and fibrosis.

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Tailored communications including personalized risk feedback can improve sun-protection behaviors and skin self-examination among adults at increased risk for skin cancer. In 22 patients with unilateral hand pain of various neurologic origins and 22 age-matched healthy controls, we studied the following parameters of cortical excitability: motor threshold at rest, motor evoked potential amplitude ratio at two intensities, cortical silent period (CSP), and intracortical inhibition (ICI) and intracortical facilitation. Novel studies have revealed a phosphorylation-independent desensitization mechanism operating through their RGS-homology (RH) domain and the recent determination of the crystal structures of GRK2 and GRK6 has uncovered interesting details on the structure-function relationships of these kinases.

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High grade gliomas, tumors involving the optic apparatus or diencepahalic structures, diffuse brainstem lesions, and recurrent or metastatic disease still pose considerable therapeutic challenges. Resolved: capillary endothelium is a major contributor to the glomerular filtration barrier. Perinatal administration of the N-methyl-Dd-aspartate (NMDA) receptor antagonist phencyclidine (PCP) has been reported to produce regionally selective apoptotic cell death in the frontal cortex.

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We also found that the LIS1 protein levels, but not the mRNA levels, were significantly reduced in alpha2(-/-) and double-mutant mice, suggesting that the catalytic subunits, especially alpha2, are a determinant of LIS1 expression level. We show that a previously uncharacterized angiogenin, Ang4, is produced by mouse Paneth cells, is secreted into the gut lumen and has bactericidal activity against intestinal microbes. Fetal cardiomyocytes retain the ability to divide and therefore can be expanded in culture.

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The most widely recognized mass-casualty triage algorithms in use today are not evidence-based, and no studies directly address these issues in the mass-casualty setting. This study tested the validity of four measures of dietary restraint: Dutch Eating Behavior Questionnaire, Eating Inventory (EI), Revised Restraint Scale (RS), and the Current Dieting Questionnaire. Squamous cell papillomatosis of esophagus following placement of a self-expanding metal stent. A second type of secretory cell (type II) that secretes neutral mucopolyssacharides opens into the median region of the intrapenial ducts. The Gaussian size distributions of bubble shape parameters are discussed.

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Under physiological conditions, PARs are mainly expressed in endothelial cells, and participate in the regulation of vascular tone, mostly by inducing endothelium-dependent relaxation. New gastroprotective ferruginol derivatives with selective cytotoxicity against gastric cancer cells.

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Depressed tumor necrosis factor alpha and interleukin-12p40 production by peripheral blood mononuclear cells of gastric cancer patients: association with IL-1R-associated kinase-1 protein expression and disease stage. L-NIL and SC-236 dose dependently inhibited C/K induced acute joint swelling, the magnitude being greatest when they were given in combination. Survival time and prevention of side effects of intraperitoneal hyperthermic perfusion with mitomycin C combined with surgery for patients with advanced gastric cancer. Prospective randomized comparison of human oocyte cryopreservation with slow-rate freezing or vitrification. Additionally, pathophysiological roles for PEDF in healing and tissue homeostasis are being revealed and our enhanced understanding of the interactions between PEDF and its receptors may yet prove useful in propelling PEDF towards clinical application.

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The 3-month-old male had undergone ligation of a patent ductus arteriosus and suffered from barotraumatic pneumomediastinum in the postoperative period. Earlier intermediates which arise and decay on the picosecond to microsecond time-scale have proven more difficult to trap. The role of the mentor in retaining junior pharmacy faculty members. Live discussion: Protein folding and neurodegeneration: biophysics to the rescue? The contact areas between bone and prosthesis were studied and measured using a specially developed reproducible method.

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Conservative surgical approach to these patients involves uterovaginal anastomosis, cervical canalization, and cervical reconstruction. However, new diabetes treatments and lifestyle interventions can be used to mitigate these problems. Cellular uptake studies of fluorescently labeled ODNs were performed using fluorescence-activated cell sorting analysis.

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VFP type artificial heart can generate the oscillated flow and can be applied to the left ventricular assist device. Furthermore, hepatic microsomal activities for pentoxyresorufin O-dealkylation (PROD) and nifedipine oxidation, which are mainly mediated by CYP2B and CYP3A subfamily enzymes, respectively, were measured. This article presents a case report in which the etiology and clinical characteristics of anterior teeth affected by enamel hypoplasia are analyzed. Other objectives were to identify variables associated with persistent PH/RV dysfunction and to analyze the 5-year survival rate for patients alive 1 month after inclusion. Fusion of hC3d3 to hCGbeta enhances responsiveness in vitro of human peripheral immunocompetent cells upon the antigen primary challenge.

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To compare the morbidity of percutaneous nephrolithotomy (PCNL) requiring multiple percutaneous tracts with that of procedures requiring a single tract for calculus clearance. Partial responders were continued on the randomized treatment until no further improvement was noted.

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To this aim 40 pregnant patients between 24th and 37th weeks gestation have been examined, considered at risk for sub-clinic loss of aminiotic fluid: 23 were affected by preterm labour and 17 by suspected rupture of membranes. The procedure included core decompression followed by insertion of a cortical bone graft in order to relieve mechanical stresses from the overlying subchondral bone. RMS fourth order also decreased significantly from 0.60 to 0.30 and the spherical aberration decreased significantly from 0.57 to 0.28. Deficient repair of DNA can increase vulnerability to oxidative stress and play a role in the premature aging, but why patients with mutations in xeroderma pigmentosum genes present with the Cockayne syndrome phenotype is still not known.

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A study of the effects of a television drama portrayal of paracetamol self-poisoning. Potentiating effect of inhaled thromboxane A2 analogue (STA2) on bronchial responsiveness in guinea pigs In the present study, we have described an in vitro spectroscopic method to evaluate the sunscreen products for UVA sun protection factor. An examination of dissolution indices in these core tops indicates that the low-carbonate zone is associated with intense dissolution. Modification of the Tet-On regulatory system prevents the conditional-live HIV-1 variant from losing doxycycline-control.

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These three cases reflect our present approach to left ventricular aneurysms after previous aortocoronary bypass (case 1), aneurysms with distorted ventricular geometry and severe mitral regurgitation (case 2), and large, minimally symptomatic left ventricular aneurysms (case 3). In vivo studies are discussed which demonstrate the applicability of IGFs, TGF betas and BMPs to increasing bone formation systemically, promoting fracture healing and inducing bone growth around implants.

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Personal influencing factors associated with pap smear testing and cervical cancer. Fourier transform-ion cyclotron resonance-mass spectrometry was used to characterize the metabolite profiles of control and elicitor-treated cell cultures. The hydroxyapatite-like layer formed at the interface was found to be compact, continuous and composed of many small crystallites with ultrastructure similar to that of natural cortical bone and dentine. Premature departure from nursing in Germany as a growing problem for the health care system -- a review

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The MICS is more feasible for brief clinical screening and performed in this study with promising correlate validity and internal consistency across ages (infancy through 3 years). Identification of protein-protein interactions is critical for understanding protein function and regulation. All lung cancers and mesotheliomas were identified from the local cancer registry, supplemented by searches at all primary care practices. The last mile of the way: understanding caregiving in African American families at the end-of-life.

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A practical strategy approach to use of reflective practice in critical care nursing. The result of method detection limit, accuracy, precision, linearity and interference studies are reported.

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Here, we report the crystal structures of VDR ligand binding domain bound to two vitamin D agonists of therapeutical interest, calcipotriol and seocalcitol, which are characterized by their side chain modifications. Coeliac disease should be a differential diagnosis in adult patients with severe acute diarrhoea and acidosis, although a rare presentation. After adjustment for depressive symptoms, elevated state anxiety was associated with higher levels of wake after sleep onset (measured by both actigraphy and sleep log) and shorter sleep onset latency (measured by sleep log).

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Administration of PBN had no effects on the motor performance of animals 3 and 6 days after SE. Based on BMI value, the patients were divided into three groups. A noncompetitive enzyme immunoassay (hetero-two-site enzyme immunoassay) for salmon calcitonin: determination of the bioavailability of subcutaneous salmon calcitonin and its correlation with the hypocalcemic activity in rats. Similar to the in vitro behavior of normal osteoblasts, cells from HO respond to leptin exposure with an increased mineralization of the extracellular matrix. Atrioventricular conduction and cardiovascular mortality: assessment of recovery PR interval is superior to pre-exercise measurement.

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Recent achievements in developing novel chemical entities and in the characterisation of the physiological and pathological role of individual metabotropic glutamate receptors in postischaemic degeneration will be reviewed. These differences are discussed in relation to the differential attraction/oviposition of the two stemborers observed in the field and, particularly for eastern African small-scale farming systems, in the context of using a push-pull strategy for their control. Although BSV does not employ integration during the infection cycle, BSV DNA was found to be integrated into the Musa genome. The results showed positive relationships between work attendance and male gender, high income, work commitment, job satisfaction, and having positive feelings towards work.

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Serotonin-GABA interactions modulate MDMA-induced mesolimbic dopamine release. Body mass index, serum glucose, insulin, insulin sensitivity index HOMA (homeostasis model assessment) and serum lipoproteins were estimated. Finding information on the risk factors of firearm-related injuries and the reasons for the steady level of intentional injuries are the next steps toward preventive measures. Xipamide is a sulfonamide-like diuretic whose action does not depend on transtubular secretion.

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Outcome measures in facial plastic surgery: patient-reported and clinical efficacy measures. This study highlights a need to increase access to hormonal contraceptives and early STI screening/treatment among blacks, improve HIV testing among whites, and increase condom use promotion for all students. Serial blood samples were collected over a period of 96 h and assayed for the plasma concentration of mifepristone by high-performance liquid chromatography. Slow oscillations in neural networks with facilitating synapses.

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By the macroscopic 2-D SHG polarimetry, we have observed that the orientation angle and organization degree of collagen fibers vary widely depending on the discrete probing positions in the reticular dermis. The mobility of fluorescent dyes of different mass and composition within controlled cross-linked environments has been measured using two-photon excited fluorescence recovery after photobleaching (FRAP).

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Interventions to reduce frequent attendance have had mixed results. An investigation on the occurrence of peri-parturient rise in trichostrongylid nematode egg output in breeding ewes was carried out on a Ranch in the semi-arid area of Kajiado District in Kenya during the period May 1999-April 2000. To evaluate the capacity of parvovirus B19 capsid protein VP2 to inhibit hematopoiesis in vitro and in vivo.

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Preclinical and clinical studies of Laromustine (formerly cloretazine, VNP-40101M), a new sulfonylhydrazine alkylator, in AML published between 2000 and September 2009 are presented and discussed. The atomic absorption analyses revealed that both enzymes contain 0.74 g-atom of nickel per mol of subunit. Hydrolysis of zirconium, neodymium (a typical surrogate for americium) and yttrium in aqueous media in the presence of acetylacetone was firstly investigated.

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All subjects were selected on the basis of normal to near normal audiometric pure tone thresholds. However, caffeine doses that reflect the daily human consumption, do not induce a release of dopamine in the shell of the nucleus accumbens but lead to a release of dopamine in the prefrontal cortex, which is consistent with caffeine reinforcing properties. This decrease in zinc tissue concentration corresponded to the healing rate of the duodenal ulcers. The aim of this case report is to describe a potential new method for treating those with primary pulmonary tuberculosis using phytochemicals via inhalation. We researched our data to determine whether use of radial artery (RA) led to similar hospital morbidity as use of pedicled internal thoracic artery (ITA) with vein grafts.

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Hyperglycosylated hCG (hCG-H) is an over-glycosylated variant of hCG. The results herein obtained allow for the prediction of how this set of antibodies can be useful for SAP detection in biologic specimens. An interesting finding was that the permeates of all the tested membranes possessed a significant potential for microbial growth, despite the low nutrient contents. Superior vena cava syndrome is most often encountered in patients with malignancies. New techniques for fixation and instrumentation for fixation of the axis are available.

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We present a case of chronic actinic dermatitis responding well to topically applied tacrolimus (Protopic) in combination with chemical and physical UV protection. The importance of GIPC in pancreatic cancer development and progression is supported by tissue microarray data of 300 pancreatic cancer specimens where GIPC is highly expressed in PCA. 1,2-Diacetyllycorine and 3-O-acetylsanguinine showed activity against Trypanosoma brucci rhodesiense, the parasite associated with sleeping sickness. Site placement of the vaccine had the unexpected effect of grounding an airman for an extended period of time. Patient motion artifacts are present in 2D sequences, but are extremely detrimental in multi-slice 3D sequences often employed in fMRI.

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Contrast-enhanced dynamic MRI should be carried out to facilitate accurate preoperative diagnosis and selection of the correct surgical plan. However, important quality problems are common and should be targeted for improvement. The stereoselective pharmacokinetics of dihydropyridine calcium antagonists were reviewed in detail in 1995. The results provide no support for the retrieval account but are generally consistent with encoding accounts. A previously validated physiologically based prognostic measure successfully stratified patients in acenocoumarol and warfarin equivalent dose radiation a large community-based sample by their risk of death.

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Antipsychotic drugs and reproductive hormones: relationship to body weight regulation. In vivo microdialysis was used girnar transport narol canada to examine the effects of tolcapone (30 mg/kg) on dopamine metabolism in amphetamine (5 mg/kg) and pargyline (75 mg/kg) treated rats. Saturation of rod-initiated signals in 2-month-old human infants. The iontophoretic application of bicuculline alone resulted in a significant increase in the evoked activity of eleven out of seventeen neurones. A 20-year-old pregnant woman was admitted with a history of 10 days of fever, chills, and diaphoresis.

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These results demonstrate the genetic basis of migratory behavior in this avian species and support the hypothesis that partial migration of populations is due to polymorphism. In vivo analysis of HPr reveals a fructose-specific phosphotransferase system that confers high-affinity uptake in Streptomyces coelicolor. Ran/TC4 is the only known tramadol depression dosage member of the family of small GTP-binding proteins primarily localized inside the nucleus. Marked reduction of lipid peroxidation intensity in the brain and plasma was recorded after both modes of stimulation. Diabetes substantially increases the risk of heart failure both in men and women, being included in the Stage A classification of heart failure by the American Societies of Cardiology.

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The use of CDT has decreased markedly since January 1996 and, since March 2000, fewer than 100 CDT vaccines per month were recorded on the ACIR, suggesting that this vaccine is not being inappropriately used. The patients with congenital insensitivity to pain and anhidrosis and absent corneal sensation showed a marked tendency to 15 mg buspirone high develop corneal ulcers that healed poorly. The advantage of EC-OWLS technique is that we could carry out kinetic studies on the behaviour of bacteria under stress conditions, and after exposure of lactobacilli to acid and oxidative stress we get faster results about the status of bacteria compared to the traditional quantitative methods.

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The formulation of sulfite-containing propofol (SCP) has not been thoroughly investigated in patients with the extensive smoking history for the effects on the total respiratory system resistance after tracheal intubation. Separate clusters of individuals reporting high levels of schizotypal and OC symptoms versus purely schizotypal symptoms emerged and demonstrated different overall symptom profiles. Throughout the 20 week trial, the cumulative proportion of ulcerated calves remained lowest in the recombinant vaccine group. This study shows a strong association between functional impairment and the use of beta-blockers after acute myocardial infarction in elderly patients. With the increasing use of ablative procedures and laparoscopy, intraoperative moxifloxacin iv vs po benadryl imaging and navigation will hold increasing significance for the HBP surgeon.

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Role of thoracoscopy in the diagnosis and treatment of lung cancer and pleural diseases In ICUs, AST detected 11 times more MRSA than clinical cultures. This study explores the intensity of medical intervention and the impact of lifestyle and other risk factors on the long-term stroke prognosis in a population-based setting of Swedish individuals with a history of stroke. Toward re-expressing tumor suppresor gene maspin in breast cancer. A rare case of a facial-nerve neurofibroma in tetracycline uses in dogs tear staining the parotid gland.

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Serpent-Tortoise, as Body-Soul, became the god Black-Warrior in charge of Earth. Secondary variables were age, vessel diameter increase, acute success rate, balloon/vessel diameter ratio, paramol dosage for amoxicillin pulmonary artery hypoplasia indices, and procedure related factors. Subcutaneous drainage versus no drainage after minilaparotomy in gynecologic benign conditions: a randomized study.