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Endoxan (Cyclophosphamide)
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Cyclophosphamide

Endoxan is a medication used as chemotherapy and to suppress the immune system. As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma. Before you begin treatment with Endoxan, you and your doctor should talk about the benefits of this medicine as well as the risks of using it. This medicine is available only with your doctor's prescription.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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Endoxan injection comes as a powder to be added to fluid and injected intravenously (into a vein) by a doctor or nurse in a medical office or hospital outpatient clinic. It may also be injected intramuscularly (into a muscle), intraperitoneally (into the abdominal cavity), or intrapleurally (into the chest cavity). The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer or condition you have.

Your doctor may need to delay your treatment or adjust your dose if you experience certain side effects. It is important for you to tell your doctor how you are feeling during your treatment with Endoxan injection.

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The development for the Japanese Society for Palliative Medicine. In this study, we have compared gene expression in the salivary glands of male Dermacentor andersoni ticks fed in the presence or absence of females to that in unfed males. The other characterizes the competition between the enzymatic kinetics and the diffusion of the substrate.

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Although non-attenders have fewer concerns, many have risk factors for diseases likely to progress without preventive measures, such as influenza vaccine and screening procedures for hypertension and breast, cervical, and prostate cancer. The full Elsevier Policy on Article Withdrawal can be found at (http://www.elsevier.com/locate/withdrawalpolicy. The infectious titer of the VSV pseudotype, derived from a stable cell line incorporating both of the chimeric glycoproteins of HCV, was approximately 4- to 5-fold higher than that of a pseudotype bearing E1-G alone or approximately 25- to 30-fold higher than that of E2-G alone when assayed with a number of mammalian cell lines. Assessing normative approaches to communicating violence risk: a national survey of psychologists. The bone marrow: a reserve of stem cells able to repair various tissues?

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Aortic valve specimens from 26 aortic valve replacement patients as well as 4 healthy control tricuspid aortic valves were included. These four cell types have been morphologically identified in multiple fish species but only limited information is available about their function. The incidence of postoperative complications in p-PVT patients does not differ from that of non-PVT patients. Top cited authors in dermatology: a citation study from 24 journals: 1982-1996. The developed selected-reaction monitoring method provided high selectivity for the investigated compounds.

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Multidimensional flow cytometry, which allows the discrimination of antigens expressed on normal and malignant cells, can detect small numbers of cancer cells in bone marrow or peripheral blood specimens. Its soluble secreted form (sAPP) shows similarities with growth factors and increases the in vitro proliferation of embryonic neural stem cells. There were many rough endoplasmic reticula and mitochondria in cytoplasm, and a lot of secretory vesicles under cell membrane and in the cytoplasm. Detailed histology of the myocardium is needed to identify such cases.

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The dimensions of 176 connectors and 124 retainers were analyzed with reference to FPD length and to number of pontics in a span. The data indicated that hGHA2 inhibited the end-stage glomerulosclerosis in diabetic rats, but hGHA1 mildly increased the glomerulosclerosis. To describe clinical findings in a case of premature ductal constriction associated with maternal use of nimesulide, a cyclo-oxygenase type-2 inhibitor. Successful allogeneic bone marrow transplantation for diamond-blackfan anemia complicated by severe cardiac dysfunction due to transfusion-induced hemochromatosis.

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To assess sensitivity to change, Guyatt effect size using change data from the placebo and actively treated patients were used. Effects of atipamezole--a selective alpha-adrenoceptor antagonist--on cardiac parasympathetic regulation in human subjects. Effects of different anesthetic and analgesic protocols on cellular immune function and stress hormone level in patients undergoing lobectomy for esophagus cancer A more complete picture is achieved by the calculation method, indicating, in some cases, higher maximum wall shear stresses than measured, confirming the original findings of the experimental work.

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The oral antidiabetic agent metformin acts at least partially via an activation of AMP-activated kinase (AMPK) in liver and muscle cells. The second part of the paper describes the work of the author on the TS mechanism, especially the catalytic roles of active site amino acids Asn177 and Glu58 in TS from Escherichia coli.

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Reasons for weaning and introduction of bottle feeding: an alternative approach to its study Tunical mesothelioma may simulate metastatic carcinoma at routine histopathological examination. The results show that: 1) for all groups the strongest correlates with SRH are health status measures, 2) for all groups the weakest correlates with SRH are demographic variables, 3) a significant relationship is found between SRH and age at immigration only for younger males, and 4) the explanatory power of social contacts and leisure activity variables varies significantly among the different groups. The development and growth of the face are intimately connected with the cranial base, which undergoes only minor changes between the ages of 0 to 25 years.

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Disrupted GABAergic circuitry has been reported in patients with schizophrenia and frontal lobe epilepsy and may contribute to their associated impairments in behavioral flexibility. Missense mutations in exon 5 (Phe144Leu) and exon 8 (Tyr229Ser, Arg238Pro) of the PMM2 gene were present in two families, but they were not present in 72 unrelated healthy Japanese individuals. The gene encoding sarcoplasmic reticulum calcium ATPase-1 (Atp2a1) maps to distal mouse chromosome 7. Parent and child distress, social support, and family environment were assessed among families of 95 children with cancer (94 mothers, 67 fathers) and 98 comparison peers (97 mothers, 77 fathers).

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Stabilization of the normally unstable engrailed RNA and protein preserved the localized striped pattern of this embryonic patterning gene during 3 days in hypoxia. The results indicate that when mesangial cells were grown in 25 mM glucose, the expression of integrin subunit alpha 2, was increased, while the alpha 1 subunit was considerably decreased, as compared to cells grown in 5 mM glucose. Computational flow visualization in the casing of vibrating flow pump (VFP) was made for various conditions based on the novel techniques of fluid dynamics. Computer overlays of film-measured and calculated planar dose distributions were used to assess the dose calculation and delivery spatial accuracy. In 10 of these patients undergoing lamivudine treatment for a mean of 19.2 months, the development of lamivudine-resistant mutations was investigated.

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Dairy heifer health management and growth programming in an intensive agricultural environment. Transcatheter arterial embolization (TAE) was performed three times. The revealed regularities were indicative of a possibility of AR involvement in androgenic action on the liver at the nuclear level.

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The isosurfaces were enhanced using transparency, lighting, shading, reflectance, and animation. The regulation in the skin of interleukin-15 (IL-15), a potent modulator of T-cell-mediated immune responses, is not fully understood. The population is estimated at 3.5 million comprising of nine ethnic groups who speak different languages. In patients with left superior vena cava (LSVC) draining to the coronary sinus (CS), the device must not obstruct CS drainage. Visual acuity, anterior segment and fundus as well as IOP, fluoroangiography and opacimetry were also examined.

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The phenotypic expression of several mutations in the cut locus of Drosophila melanogaster is modified by mutations in the zeste, e(y)2 and e(y)3 genes and in some genes of the Polycomb group. parasites, and one strategy has been the analysis of naturally occurring plant-derived compounds, including naphthylisoquinoline alkaloids. Temporal variations of CO2 concentration near land surface and its response to meteorological variables in Heihe River Basin, northwest China.

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The pathogenesis of this unique finding probably involves transient retinal vein hypertension and reflex vasospasm in the retina. Degradation of IGFBP-4 by PAPP-A or MC3T3-E1 conditioned medium was enhanced by IGF-II but inhibited by mutation of basic residues at or near the PAPP-A cleavage site in IGFBP-4. The correlation between the maximal mouth opening and the movement of the condyle was also significant. The decapentaplegic (Dpp) gradient in the Drosophila wing imaginal disc has emerged as a suitable and established system to study organ growth.

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Effects of Paxillus on the growth and PA fluctuation, excluding root free Spd, of the host plant resembled that observed in our previous in vitro study on S. Regulatory interplay between proton motive force, ADP, phosphate, and subunit epsilon in bacterial ATP synthase. Nausea and vomiting were infrequent, and no excess sedation, untoward side effects, or complications were noted. There is also a strong correlation between hyperphosphorylated mitotic forms of Mps1 and increased kinase activity.

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Abstract An oddball paradigm was used to investigate brain processes elicited by spoken words and pseudowords played monaurally, to the left or right ear, or simultaneously to both ears of human subjects instructed to ignore acoustic stimuli but watch a silent video film. In spite of the widespread use of prenatal care utilization indices in the scientific literature, little attention has been given to the extent to which these indices are comparable. Age-related changes in antioxidant enzyme activities in the small intestine and liver from Wistar rats. Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop. Replicating genetically modified adenoviruses have shown promise as a new treatment approach against cancer.

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In apicomplexan parasites, gliding motility and host cell invasion are driven by an actomyosin-based system. A detailed morphological evaluation of the evolution of the haemostatic plug in normal, factor VII and factor VIII deficient dogs. Charge matching locally increases the concentration of negatively charged lipids, lateral lipid diffusion locally decreases.

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Studies have shown that temporal lobe epilepsy in children is not systematically associated with global mental retardation. Such an environmental reconstruction provides a new perspective for Clovis adaptations and the ecological tolerances of Mammut americanum. Research in this direction should not be abandoned and further studies are necessary to elucidate the exact role of common infections in the pathogenesis and development of CPD and how this can be translated into novel pharmacological approaches for prevention and treatment. Functional analysis of HvGAMYB by transient expression of C terminal HvGAMYB deletions in barley aleurone cells identified two transcriptional activation domains (TADs) which function in transcriptional regulation of both high- and low-pl alpha-amylase promoters. Musculoskeletal disorders are common in people who undertake adventure travel to the Antarctic, and in those who support them, because of the hard physical demands and lack of rest.

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Production of proinflammatory cytokines by syncytiotrophoblasts infected with human cytomegalovirus isolates. A second-generation compound designed on the basis of the interaction model shows a 200-fold increase in antiviral activity, creating the basis for novel MV therapeutics. Both forms were associated with intranuclear B and C capsids, yet only the 58-kDa polypeptide was found in enveloped cytoplasmic virions. The physiological demands of the exercise stimulus influenced affective responses through themes related to the interpretation of physiological symptoms and the physiological state of the body. Both the nucleotide sequence of CiLRV RNA 1 and its translated polypeptide share similarities with those of the RNA 1 of alfalfa mosaic virus.

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EDAG-1 mRNA and protein were highly expressed in erythroleukemia cell lines (K-562, HEL), megakaryoblast leukemia cell lines (DAMI, MEG-01), and T cell leukemia cell line (Jurkat), while no gene mutation was found in coding region, no amplification and rearrangement of genome was detected in these cell lines. The repressor-mediated repression process in bacteria is modelled using a gene-enzyme-endproduct control unit.

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Intact A1PI concentrates contained mainly diantennary, disialylated and smaller amounts of triantennary, trisialylated N-glycans. Together, our findings implicate that in human cells BRCA1 binding to FANCJ is critical to regulate DNA repair choice and promote genomic stability. Double reading was simulated combining conventional readings of four expert radiologists and compared with CAD reading.

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Disruption of tubulin cytoskeleton with nocodazole reduced capsaicin-evoked currents in cells expressing TRPV1 and GABARAP, without affecting the kinetics of vanilloid-induced desensitization. It therefore seems impossible to obtain valid retrospective determination from parents and the only solution is to have accurate information in the birth records. Liver transplantation remains the only definitive treatment for patients with end-stage primary biliary cirrhosis, although the optimal timing of the procedure remains uncertain.

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Whether estriol reflects a causal mechanism by which women on antidepressants have shorter pregnancy duration remains to be further studied. At 10-12 years of age, the elevations of BAEP thresholds and the declines of BAEP amplitudes in older animals were also observed. Cell survival was determined after the 72 h ara-C exposure by double cytofluorescence assay with fluorescein diacetate and propidium iodide.

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The use of a test check for a computer-assisted examination on the organization of medical support for the troops Horizontal and vertical variability of mercury species in pore water and sediments in small lakes in Ontario. This cardio-inhibitory response depended on the integrity of the vagus nerves and was particularly marked upon stimulation in the caudal medulla, the areas of the ambiguus, solitary and dorsomotor nuclei of the vagus and the midline structures. The central Pro9 residue and the entire sequence of P18 are essential for its full fungicidal activity. One mouse developed a reticulum cell sarcoma, one developed lymphoma and one developed interstitial nephritis.

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Finite element method (FEM) modelling is necessary to carry out precise and individual volume analysis and in the future will form the basis for simulation of cardiac interventions. Systematic research using Medline, EBSCOhost and Science Direct (ISI Web of Knowledge) was conducted to analyse various VR rehabilitation methods, and we developed a framework to characterise different research findings. Stereospecific deuteration of alpha-furanosyl azomycin nucleosides: a model reaction for tritium radiolabeling. The use of vicryl mesh in 200 porous orbital implants: a technique with few exposures.

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Technique for internal fixation of capitellum and lateral trochlea fractures. Male Sprague-Dawley rats were randomly divided into normal, 4 d, 2 wk, 4 wk, 9 wk and 11 wk groups, and the model rats were fed with a mixture of alcohol by gastric infusion at the designed time, respectively, then decollated and their livers were harvested for the examination of MMP-2, MMP-3, MMP-9, MMP-13, TIMP-1 and TIMP-2 by immunohistochemistry, zymograghy and Western blotting, respectively. As a better understanding of how diverse factors influence healing is gained, the use of interventions that modulate these factors becomes possible and potentially beneficial. Integration of the antennal lobe glomeruli and three projection neurons in the standard brain atlas of the moth heliothis virescens. A total of 59 green hybrid colonies have been isolated followed by spectinomycin/streptomycin selection.

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This review focuses on 31P, 1H and 13C MR spectroscopy for assessment of the dynamics of muscle metabolism and on dynamic 1H MRI methods for non-invasive measurement of the biomechanical and functional properties of skeletal muscle. The next step comprises the selection of relevant UCSC genome annotation tracks for display in the final graph. It is relatively cost-effective compared with a number of other interventions provided by the NHS. Mycobacteria in water and loose deposits of drinking water distribution systems in Finland.

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Isolated rupture of membranous part of trachea during closed chest trauma in child A randomized controlled study should be conducted in advanced gastric cancer patients with a single non-curative factor to confirm the usefulness of palliative gastrectomy followed by chemotherapy shown here. Preliminary results of dose intensification in small cell lung cancer are described and future prospects discussed. Individual records consisted of repeated serum IgG measurements at irregular intervals for up to 10 years post diagnosis.

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The effects of organic modifier, mobile phase composition, pH and flow rate on the separation were investigated. In this review, the current role of chemotherapy and targeted molecular agents for brain metastases is summarized and future directions are discussed.

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Hollow-fiber flow field-flow fractionation for whole bacteria analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. It was assessed by immunohistochemistry in a semiquantitative way by the intensity of staining and by the percentage of positive cells. Quantitative evaluation showed statistically significant improvement in correct responses for the 14 questions measured with an average increase in correct responses from 8.95 to 10.23.

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The present data strongly suggest that phospho-GAP43 plays an active role in both the early and late stages of optic nerve regeneration in fish. Psychoeducation about postinjury reactions and attention to structural barriers to services may help increase rates of care in this population. Characterization of the receptor mediating the effect of calcitonin gene-related peptide in the frog adrenal gland. Abnormalities identified at colonoscopy were compared between suspected IBS and control groups. Neuropsychological testing was performed at the index assessment and repeated at 12 months in 30 stroke/TIA patients and 49 controls, and at 3 years in 25 patients and 48 controls.

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Vigilant identification of high-risk patients and provision of all proved preventive measures must suffice until new methods of prevention are identified and validated. The growth and development of adipose tissue are thought to be associated with angiogenesis and extracellular matrix remodeling. They have attracted the attention not only of healthcare consumers, providers, and payors but also of scholars from various disciplines. We find that overexpression of an hMps1-T676A mutation inhibits centrosome duplication in RPE1 cells. faecalis associated with rice roots was investigated under the condition of the associative nitrogen fixation using X-Gal decoration method, micrograph and ntrC partially deletion mutant.

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marinus represents a key organism in the taxonomic separation of the single-celled eukaryotes collectively known as meloxicam abuse potential meaning the alveolates, and our data imply a lineage in which ancestral acquisition of plant-like genes, such as FAE1-like 3-ketoacyl-CoA synthases, occurred via endosymbiosis. For a long time it was thought that Nietzsche suffered from general paralysis of the insane (GPI).

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Adeno-associated virus type 2 (AAV-2) establishes latency by site-specific integration into a unique locus, ofloxacin ear drops expired medication AAVS1, on human chromosome 19 (chr19). In the present study, we examined the effects of sperm swimming velocity, the proportion of motile spermatozoa, sperm head and tail length and the proportion of live spermatozoa on fertilisation success in the externally fertilising myobatrachid frog Crinia georgiana using IVF techniques and by controlling sperm numbers. Immunohistochemistry (IHC) for p53, MIB-1, and Aurora-A was performed on tissue microarray sections from tumor tissue. These findings may provide evidence that a glial glutamate transporter GLT-1 could be a new target for preventing physical and psychological morphine dependence.

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Activation and inactivation of volume-sensitive taurine efflux from rat mammary gland. The two overseas populations from Iceland and Canada were shown to result from rare LDD events, and exhibited signatures of strong founder effects. This article describes the development and evaluation of an HIV education program for mental health care providers at three psychiatric institutions in South Africa. The antibacterial activity of amoebapores and of related polypetides from free-living protozoa points to a more vital function of these molecules: inside the digestive vacuoles they combat growth of phagocytosed bacteria which are killed starlix contraindications of tramadol when their cytoplasmic membranes are permeabilized. Few studies have investigated the epidemiology of sepsis and septic shock in a large population and none have been from Canada.